Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00852 ...
Drug Name Pseudoephedrine
Molecular Weight 165.2322
Molecular Formula C10H15NO
CAS Number 90-82-4
SMILES CN[C@@H](C)[C@@H](O)C1=CC=CC=C1
External Links
DRUGBANK DB00852
T3DB T3D4555
PubChem Compound 7028
PDR 310
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 0.89 - 0.89 - KRIL,MB & FUNG,HL (1990)
Melting Point 119.0 ℃ 119 ℃ PhysProp
pKa 10.3 - 10.3 - PERRIN,DD (1965)

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
AUC 6862.0 ng.h/ml 6862.0±334.1 ng.h/ml PO, oral; food; DRUGBANK
AUC 7535.1 ng.h/ml 7535.1±333.0 ng.h/ml PO, oral; fasting; DRUGBANK
Bioavailability 100.0 % ~100 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 246.3 null 246.3±10.5 null PO, oral; DRUGBANK
C Max 246.3 ng/ml 246.3±10.5 ng/ml PO, oral; food; DRUGBANK
C Max 272.5 ng/ml 272.5±13.4 ng/ml PO, oral; fasting; DRUGBANK
C Max 268.5 ng/ml 177-360 ng/ml Oral single dose; immediate release formulation; The Pharmacological Basis of Therapeutics
C Max 289.5 ng/ml 265-314 ng/ml Oral single dose; extended release formulation; The Pharmacological Basis of Therapeutics
T Max 6.6 h 6.60±1.38 h PO, oral; food; DRUGBANK
T Max 11.9 h 11.87±0.72 h PO, oral; fasting; DRUGBANK
T Max 1.7 h 1.4-2 h Oral single dose; immediate release formulation; The Pharmacological Basis of Therapeutics
T Max 5.0 h 3.8-6.1 h Oral single dose; extended release formulation; The Pharmacological Basis of Therapeutics
Metabolic 1.0 % <1 % Inactive metabolite; DRUGBANK
Clearance 0.35 L/h/kg 5.9±1.7 ml/min/kg PO, oral; DRUGBANK
Clearance 0.44 L/h/kg 7.33 ml/min/kg hydrolysis; The Pharmacological Basis of Therapeutics
Volume of Distribution 3.0 L/kg 2.6-3.3 L/kg Apparent volume of distribution; DRUGBANK
Volume of Distribution 3.1 L/kg 2.64-3.51 L/kg The Pharmacological Basis of Therapeutics
Half-life 6.0 h 6 h elimination half-life; DRUGBANK
Half-life 6.2 h 4.3-8 h PO, oral; Urine alkaline ↑ ; The Pharmacological Basis of Therapeutics
Toxicity LD50 2206.0 mg/kg 2206.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 726.0 mg/kg 726.0 mg/kg PO, oral; mouse; DRUGBANK
Eliminate Route 65.0 % 55-75 % Urinary excretion; PO, oral; Unchanged drug; DRUGBANK
Eliminate Route 69.5 % 43-96 % Urinary excretion; adults; normal,healthy; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 6.6 % 6.6±0.4 % Raceme L; human, homo sapiens; DRUGBANK
Protein Binding 22.5 % 22.5±3.2 % Raceme L; human, homo sapiens; DRUGBANK
Protein Binding 6.7 % 6.7±1.2 % Raceme D; human, homo sapiens; DRUGBANK
Protein Binding 25.4 % 25.4±3.9 % Raceme D; human, homo sapiens; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 240.0 mg/day 240 mg/day PO, oral Children's Sudafed Non-Drowsy pseudoephedrine hydrochloride PDR
Max dose for children 120.0 mg/day 120 mg/day PO, oral Children's Sudafed Non-Drowsy pseudoephedrine hydrochloride PDR
Max dose for children 60.0 mg/day 60 mg/day PO, oral Children's Sudafed Non-Drowsy pseudoephedrine hydrochloride PDR
Max dose for children 60.0 mg/day 60 mg/day PO, oral Children's Sudafed Non-Drowsy pseudoephedrine hydrochloride PDR
Max dose for adolescents 240.0 mg/day 240 mg/day PO, oral Children's Sudafed Non-Drowsy pseudoephedrine hydrochloride PDR
Max dose for adults 240.0 mg/day 240 mg/day PO, oral Children's Sudafed Non-Drowsy pseudoephedrine hydrochloride PDR
Max dose for geriatric 240.0 mg/day 240 mg/day PO, oral Children's Sudafed Non-Drowsy pseudoephedrine hydrochloride PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1