Basic Information
| Drug ID | DDPD00851 |
|
| Drug Name | Dacarbazine | |
| Molecular Weight | 182.187 | |
| Molecular Formula | C6H10N6O | |
| CAS Number | 4342-03-4 | |
| SMILES | CN(C)\N=N\C1=C(N=CN1)C(N)=O | |
| External Links | ||
| DRUGBANK | DB00851 | |
| T3DB | T3D4689 | |
| PubChem Compound | 5351166 | |
| PDR | 976 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -0.24 | - | -0.24 | - | HANSCH,C ET AL. (1995) |
| Melting Point | 205.0 | ℃ | 205 | ℃ | PhysProp |
| Water Solubility | 4220.0 | mg/L | 4220 | mg/L | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 0.16 | L/h/kg | 2.6 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 1.2 | L/kg | 1.2 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 5.0 | h | 5 | h | DRUGBANK | Half-life | 6.2 | h | 6.2 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 350.0 | mg/kg | 350.0 | mg/kg | PO, oral; mouse; | DRUGBANK | Toxicity LD50 | 350.0 | mg/kg | 350.0 | mg/kg | PO, oral; mouse; | T3DB |
| Protein Binding | 5.0 | % | <5 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 375.0 | mg/m2/dose | 375 | mg/m2/dose | intravenous injection, IV | Dacarbazine | dacarbazine | PDR |
| Max dose for children | 900.0 | mg/m2/dose | 900 | mg/m2/dose | intravenous injection, IV | Dacarbazine | dacarbazine | PDR |
| Max dose for adolescents | 375.0 | mg/m2/dose | 375 | mg/m2/dose | intravenous injection, IV | Dacarbazine | dacarbazine | PDR |
| Max dose for adolescents | 900.0 | mg/m2/dose | 900 | mg/m2/dose | intravenous injection, IV | Dacarbazine | dacarbazine | PDR |
| Max dose for adults | 1000.0 | mg/m2/dose | 1000 | mg/m2/dose | intravenous injection, IV | Dacarbazine | dacarbazine | PDR |
| Max dose for elderly | 1000.0 | mg/m2/dose | 1000 | mg/m2/dose | intravenous injection, IV | Dacarbazine | dacarbazine | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1