Basic Information
| Drug ID | DDPD00850 |
|
| Drug Name | Perphenazine | |
| Molecular Weight | 403.969 | |
| Molecular Formula | C21H26ClN3OS | |
| CAS Number | 58-39-9 | |
| SMILES | OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(Cl)C=C3)CC1 | |
| External Links | ||
| DRUGBANK | DB00850 | |
| T3DB | T3D2913 | |
| PubChem Compound | 4748 | |
| PDR | 1592 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 4.2 | - | 4.2 | - | HANSCH,C ET AL. (1995) |
| Boiling Point | 279.5 | ℃ | 278-281 | ℃ | PhysProp |
| Melting Point | 97.0 | ℃ | 97 | ℃ | PhysProp |
| Water Solubility | 28.3 | mg/L | 28.3 | mg/L | YALKOWSKY,SH & DANNENFELSER,RM 1992) |
| pKa | 7.94 | - | 7.94 | - | SANGSTER (1994) |
| Log S | -4.16 | - | -4.16 | - | ADME Research, USCD |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 40.0 | % | 40 | % | PO, oral; | DRUGBANK |
| Clearance | 1.6 | L/h/kg | 27 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 18.0 | L/kg | 18 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 14.0 | h | 8-12(8-20) | h | DRUGBANK | Half-life | 9.4 | h | 9.4 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 318.0 | mg/kg | 318.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 64.0 | mg/kg | 64.0 | mg/kg | Intraperitoneal, IP; mouse; | DRUGBANK | Toxicity LD50 | 318.0 | mg/kg | 318.0 | mg/kg | PO, oral; Rattus, Rat; | T3DB | Toxicity LD50 | 64.0 | mg/kg | 64.0 | mg/kg | Intraperitoneal, IP; mouse; | T3DB |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 24.0 | mg/day | 24 | mg/day | PO, oral | Perphenazine | perphenazine | PDR |
| Max dose for children | 64.0 | mg/day | 64 | mg/day | PO, oral | Perphenazine | perphenazine | PDR |
| Max dose for adolescents | 24.0 | mg/day | 24 | mg/day | PO, oral | Perphenazine | perphenazine | PDR |
| Max dose for adolescents | 64.0 | mg/day | 64 | mg/day | PO, oral | Perphenazine | perphenazine | PDR |
| Max dose for adults | 24.0 | mg/day | 24 | mg/day | PO, oral | Perphenazine | perphenazine | PDR |
| Max dose for adults | 64.0 | mg/day | 64 | mg/day | PO, oral | Perphenazine | perphenazine | PDR |
| Max dose for geriatric | 24.0 | mg/day | 24 | mg/day | PO, oral | Perphenazine | perphenazine | PDR |
| Max dose for geriatric | 64.0 | mg/day | 64 | mg/day | PO, oral | Perphenazine | perphenazine | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1