Basic Information
| Drug ID | DDPD00845 |
|
| Drug Name | Clofazimine | |
| Molecular Weight | 473.396 | |
| Molecular Formula | C27H22Cl2N4 | |
| CAS Number | 2030-63-9 | |
| SMILES | CC(C)N=C1C=C2N(C3=CC=C(Cl)C=C3)C3=C(C=CC=C3)N=C2C=C1NC1=CC=C(Cl)C=C1 | |
| External Links | ||
| DRUGBANK | DB00845 | |
| PubChem Compound | 2794 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 7.66 | - | 7.66 | - | QUIGLEY,JM ET AL. (1990) |
| Melting Point | 211.0 | ℃ | 210-212 | ℃ | PhysProp |
| Water Solubility | 0.225 | mg/L | 0.225 | mg/L | DRUGBANK |
| pKa | 8.51 | - | 8.51 | - | QUIGLEY,JM ET AL. (1990) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| Absorption | 53.5 | % | 45-62 | % | PO, oral; leprosy; | DRUGBANK | |
| C Max | 410.0 | ng/ml | 0.41 | mg/L | PO, oral; food; | DRUGBANK | |
| T Max | 8.0 | h | 8 | h | PO, oral; food; | DRUGBANK | T Max | 12.0 | h | 12 | h | PO, oral; fasting; | fasting ↑ ; | DRUGBANK |
| Half-life | 600.0 | h | ~25 | day | elimination half-life; | DRUGBANK | |
| Toxicity LD50 | 8400.0 | mg/kg | 8400.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 5000.0 | mg/kg | >5000 | mg/kg | PO, oral; mouse; | DRUGBANK |
| Eliminate Route | 0 | % | ~0 | % | Urinary excretion; Unchanged drug; | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1