Basic Information
| Drug ID | DDPD00844 |
|
| Drug Name | Nalbuphine | |
| Molecular Weight | 357.4434 | |
| Molecular Formula | C21H27NO4 | |
| CAS Number | 20594-83-6 | |
| SMILES | O[C@H]1CC[C@@]2(O)[C@H]3CC4=CC=C(O)C5=C4[C@@]2(CCN3CC2CCC2)[C@H]1O5 | |
| External Links | ||
| DRUGBANK | DB00844 | |
| T3DB | T3D2911 | |
| PubChem Compound | 5311304 | |
| PDR | 1508 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 1.4 | - | 1.4 | - | DRUGBANK |
| Melting Point | 230.0 | ℃ | 230 | ℃ | DRUGBANK |
| Water Solubility | 35500.0 | mg/L | 35.5 | mg/ml | DRUGBANK |
| pKa | 8.71 | - | 8.71,9.96 | - | FDA Label | pKa | 9.96 | - | 8.71,9.96 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 81.0 | % | 81 | % | IM,intramuscular injection; | DRUGBANK | Bioavailability | 83.0 | % | 83 | % | IM,intramuscular injection; | DRUGBANK | Bioavailability | 79.0 | % | 79 | % | subcutaneous injection, SC; | DRUGBANK | Bioavailability | 76.0 | % | 76 | % | subcutaneous injection, SC; | DRUGBANK |
| Clearance | 1.3 | L/h/kg | 22 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 4.6 | L/kg | 4.6 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 5.0 | h | ~5 | h | elimination half-life; | DRUGBANK | Half-life | 3.7 | h | 3.7 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 1100.0 | mg/kg | 1100.0 | mg/kg | PO, oral; dog; | DRUGBANK | Toxicity LD50 | 1100.0 | mg/kg | 1100.0 | mg/kg | PO, oral; dog; | T3DB |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 20.0 | mg/dose | 20 | mg/dose | intravenous injection, IV;IM,intramuscular injection;subcutaneous injection, SC; | Nalbuphine Hydrochloride | nalbuphine hydrochloride | PDR |
| Max dose for adults | 160.0 | mg/day | 160 | mg/day | intravenous injection, IV;IM,intramuscular injection;subcutaneous injection, SC; | Nalbuphine Hydrochloride | nalbuphine hydrochloride | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1