| Property Name |
Property Value |
Unit |
Raw Value |
Raw Unit |
Annotation |
Factor |
Reference |
| AUC |
223.6 |
ng.h/ml |
221.9-225.36 |
ng.h/ml |
Tablet, PO, oral; |
|
DRUGBANK |
| Bioavailability |
100.0 |
% |
100 |
% |
PO, oral; |
|
DRUGBANK |
| C Max |
8.3 |
ng/ml |
8.34 |
ng/ml |
Tablet, PO, oral; |
|
DRUGBANK |
C Max |
30.8 |
ng/ml |
30.8±4.2 |
ng/ml |
PO, oral; |
|
The Pharmacological Basis of Therapeutics |
| T Max |
3.5 |
h |
3-4 |
h |
PO, oral; |
|
DRUGBANK |
T Max |
4.1 |
h |
4.1±1.5 |
h |
PO, oral; different study; |
|
DRUGBANK |
T Max |
3.5 |
h |
3-4 |
h |
PO, oral; |
|
The Pharmacological Basis of Therapeutics |
| Tss |
432.0 |
h |
15-21 |
day |
PO, oral; |
|
DRUGBANK |
| Clearance |
0.16 |
L/h/kg |
0.13-0.19 |
L/h/kg |
Plasma clearance; |
|
DRUGBANK |
Clearance |
0.11 |
L/h/kg |
0.110±0.02 |
L/h/kg |
Plasma clearance; normal,healthy; patients; |
Hepatitis, Hep ↓ ; |
DRUGBANK |
Clearance |
0.17 |
L/h/kg |
2.90±0.74 |
ml/min/kg |
apparent clearance; PO, oral; hydrolysis; hydrolysis; metabolism of ugt; young; adults; Male, men; Female, women; |
hepatopathy，LD ↓ ;RD, renal impairment, Renal disease，including uremia → ; |
The Pharmacological Basis of Therapeutics |
| Volume of Distribution |
11.8 |
L/kg |
11.8 ± 1.7 |
L/kg |
|
|
DRUGBANK |
Volume of Distribution |
11.6 |
L/kg |
11.6 ± 1.91 |
L/kg |
|
|
DRUGBANK |
Volume of Distribution |
14.0 |
L/kg |
12-16.0 |
L/kg |
at steady state; |
|
DRUGBANK |
Volume of Distribution |
14.0 |
L/kg |
14.0±2.42 |
L/kg |
Apparent volume of distribution; PO, oral; hydrolysis; hydrolysis; metabolism of ugt; young; adults; Male, men; Female, women; |
Elderly ↑ ; |
The Pharmacological Basis of Therapeutics |
| Half-life |
70.0 |
h |
~70 |
h |
elimination half-life; |
|
DRUGBANK |
Half-life |
81.5 |
h |
81.5±22 |
h |
|
|
DRUGBANK |
Half-life |
59.7 |
h |
59.7±16.1 |
h |
young; normal,healthy; Male, men; Female, women; PO, oral; |
Age ↑ ; |
The Pharmacological Basis of Therapeutics |
| Toxicity LD50 |
32.6 |
mg/kg |
32.6 |
mg/kg |
PO, oral; Rattus, Rat; |
|
DRUGBANK |
| Eliminate Route |
57.0 |
% |
57 |
% |
Urinary excretion; adults; normal,healthy; human, homo sapiens; |
|
DRUGBANK |
Eliminate Route |
5.0 |
% |
5 |
% |
Faeces excretion; adults; normal,healthy; guinea pigs; |
|
DRUGBANK |
Eliminate Route |
10.6 |
% |
10.6±2.7 |
% |
Urinary excretion; adults; human, homo sapiens; Unchanged drug; |
|
The Pharmacological Basis of Therapeutics |
| Protein Binding |
96.0 |
% |
96 |
% |
|
|
DRUGBANK |
Protein Binding |
75.0 |
% |
~75 |
% |
|
|
DRUGBANK |
Protein Binding |
21.0 |
% |
~21 |
% |
|
|
DRUGBANK |
Protein Binding |
92.6 |
% |
92.6±0.9 |
% |
young; normal,healthy; human, homo sapiens; |
|
The Pharmacological Basis of Therapeutics |
