Basic Information
| Drug ID | DDPD00842 |
|
| Drug Name | Oxazepam | |
| Molecular Weight | 286.713 | |
| Molecular Formula | C15H11ClN2O2 | |
| CAS Number | 604-75-1 | |
| SMILES | OC1N=C(C2=CC=CC=C2)C2=C(NC1=O)C=CC(Cl)=C2 | |
| External Links | ||
| DRUGBANK | DB00842 | |
| T3DB | T3D2909 | |
| PubChem Compound | 4616 | |
| PDR | 1581 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 2.24 | - | 2.24 | - | HANSCH,C ET AL. (1995) |
| Melting Point | 205.5 | ℃ | 205-206 | ℃ | PhysProp |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| C Max | 450000000.0 | ng/ml | 450.0 | mg/ml | PO, oral; | DRUGBANK |
| T Max | 3.0 | h | 3 | h | PO, oral; | DRUGBANK |
| Clearance | 0.0660 | L/h/kg | 1.1 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.59 | L/kg | 0.59 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 8.2 | h | 8.2 | h | elimination half-life; | DRUGBANK | Half-life | 6.7 | h | 6.7 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 8000.0 | mg/kg | >8000 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 1540.0 | mg/kg | 1540.0 | mg/kg | PO, oral; mouse; | DRUGBANK |
| Eliminate Route | 21.0 | % | ~21 | % | Faeces excretion; Unchanged drug; | DRUGBANK |
| Protein Binding | 89.0 | % | ~89 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 1.0 | mg/kg/day | 1 | mg/kg/day | PO, oral | Oxazepam | oxazepam | PDR |
| Max dose for adolescents | 120.0 | mg/day | 120 | mg/day | PO, oral | Oxazepam | oxazepam | PDR |
| Max dose for adults | 120.0 | mg/day | 120 | mg/day | PO, oral | Oxazepam | oxazepam | PDR |
| Max dose for geriatric | 60.0 | mg/day | 60 | mg/day | PO, oral | Oxazepam | oxazepam | PDR |
| Max dose for geriatric | 120.0 | mg/day | 120 | mg/day | PO, oral | Oxazepam | oxazepam | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1