Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00836 ...
Drug Name Loperamide
Molecular Weight 477.038
Molecular Formula C29H33ClN2O2
CAS Number 53179-11-6
SMILES CN(C)C(=O)C(CCN1CCC(O)(CC1)C1=CC=C(Cl)C=C1)(C1=CC=CC=C1)C1=CC=CC=C1
External Links
DRUGBANK DB00836
PubChem Compound 3955
PDR 2664
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 5.5 - 5.5 - DRUGBANK
Melting Point 222.1 ℃ 222.1 ℃ U.S. Patent 3,714,159; 3,884,916.

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Half-life 10.8 h 10.8(9.1-14.4) h DRUGBANK
Toxicity LD50 105.0 mg/kg 105.0 mg/kg PO, oral; mouse; DRUGBANK
Protein Binding 97.0 % 97 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for neonates 0.0 0 Loperamide Hydrochloride Capsules loperamide hydrochloride PDR
Max dose for infants 0.0 0 Loperamide Hydrochloride Capsules loperamide hydrochloride PDR
Max dose for children 8.0 mg/day 8 mg/day PO, oral Loperamide Hydrochloride Capsules loperamide hydrochloride PDR
Max dose for children 16.0 mg/day 16 mg/day PO, oral Loperamide Hydrochloride Capsules loperamide hydrochloride PDR
Max dose for children 6.0 mg/day 6 mg/day PO, oral Loperamide Hydrochloride Capsules loperamide hydrochloride PDR
Max dose for children 4.0 mg/day 4 mg/day PO, oral Loperamide Hydrochloride Capsules loperamide hydrochloride PDR
Max dose for children 3.0 mg/day 3 mg/day PO, oral Loperamide Hydrochloride Capsules loperamide hydrochloride PDR
Max dose for adolescents 8.0 mg/day 8 mg/day PO, oral Loperamide Hydrochloride Capsules loperamide hydrochloride PDR
Max dose for adolescents 16.0 mg/day 16 mg/day PO, oral Loperamide Hydrochloride Capsules loperamide hydrochloride PDR
Max dose for adults 8.0 mg/day 8 mg/day PO, oral Loperamide Hydrochloride Capsules loperamide hydrochloride PDR
Max dose for adults 16.0 mg/day 16 mg/day PO, oral Loperamide Hydrochloride Capsules loperamide hydrochloride PDR
Max dose for geriatric 8.0 mg/day 8 mg/day PO, oral Loperamide Hydrochloride Capsules loperamide hydrochloride PDR
Max dose for geriatric 16.0 mg/day 16 mg/day PO, oral Loperamide Hydrochloride Capsules loperamide hydrochloride PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1