Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00829 ...
Drug Name Diazepam
Molecular Weight 284.74
Molecular Formula C16H13ClN2O
CAS Number 439-14-5
SMILES CN1C2=C(C=C(Cl)C=C2)C(=NCC1=O)C1=CC=CC=C1
External Links
DRUGBANK DB00829
T3DB T3D2903
PubChem Compound 3016
PDR 2100
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Caco-2 Permeability -4.32 - -4.32 - ADME Research, USCD
Log P 2.82 - 2.82 - SANGSTER (1994)
Melting Point 125.5 ℃ 125-126 ℃ Chase, G.; U.S. Patent 3,102,116; August 27, 1963; assigned to Hoffmann-La Roche Inc. Reeder, E. and Sternbach, L.H.; U.S. Patent 3,109,843; November 5, 1963; assigned to Hoffmann-La Roche lnc. Reeder, E. and Sternbach, L.H.; U.S. Patent 3,136,815; June 9, 1964; assigned to Hoffmann- La Roche Inc. Reeder, E. and Sternbach, L.H.; US. Patent 3,371,085; February 27, 1968; assigned to Hoffmann-La Roche Inc.
Water Solubility 50.0 mg/L 50 mg/L YALKOWSKY,SH & DANNENFELSER,RM 1992)
pKa 3.4 - 3.4 - MERCK INDEX (1996)

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 90.0 % >90 % PO, oral; DRUGBANK
Bioavailability 100.0 % 100±14 % PO, oral; The Pharmacological Basis of Therapeutics
Bioavailability 90.0 % 90.0 % Rectal Administration; The Pharmacological Basis of Therapeutics
C Max 317.0 ng/ml 317±27 ng/ml Oral single dose; adults; normal,healthy; The Pharmacological Basis of Therapeutics
C Max 400.0 ng/ml ~400 ng/ml Rectal Administration; adults; normal,healthy; The Pharmacological Basis of Therapeutics
C Max 450.0 ng/ml 400-500 ng/ml adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 1.3 h 1-1.5（0.25-2.5） h PO, oral; DRUGBANK
T Max 2.5 h 2.5 h PO, oral; food; food ↑ ; DRUGBANK
T Max 1.3 h 1.3±0.2 h Oral single dose; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 1.5 h 1.5 h Rectal Administration; adults; normal,healthy; The Pharmacological Basis of Therapeutics
Clearance 1.5 L/h 20-30 ml/min young; adults; DRUGBANK
Clearance 0.0228 L/h/kg 0.38±0.06 ml/min/kg Elderly → ;Hepatic cirrhosis, cirr ↓ ;hyperthyroid, HTh → ;hypoalbuminemia ↑ ;Somking → ; The Pharmacological Basis of Therapeutics
Clearance 0.0228 L/h/kg 0.38 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.90 L/kg 0.8-1 L/kg at steady state; normal,healthy; young; Male, men; DRUGBANK
Volume of Distribution 1.1 L/kg 1.1±0.3 L/kg Elderly ↑ ;Hepatic cirrhosis, cirr ↑ ;RD, renal impairment, Renal disease，including uremia → ;hyperthyroid, HTh → ;hypoalbuminemia ↑ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 1.0 L/kg 1 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 36.0 h 1-2 day elimination half-life; Neonates ↑ ;Elderly ↑ ;hepatopathy，LD ↑ ;RD, renal impairment, Renal disease，including uremia ↑ ; DRUGBANK
Half-life 84.0 h 2-5 day DRUGBANK
Half-life 43.0 h 43±13 h Active metabolite; Hepatic cirrhosis, cirr ↑ ;hyperthyroid, HTh → ;Age ↑ ; The Pharmacological Basis of Therapeutics
Half-life 42.0 h 42 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 1200.0 mg/kg 1200.0 mg/kg PO, oral; Rattus, Rat; T3DB
Toxicity LD50 1000.0 mg/kg 1000.0 mg/kg PO, oral; dog; T3DB
Toxicity LD50 700.0 mg/kg 700.0 mg/kg PO, oral; mouse; T3DB
Eliminate Route 1.0 % <1 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 98.5 % 98-99 % DRUGBANK
Protein Binding 98.7 % 98.7±0.2 % Preg, pregnant ↓ ;Neonates ↓ ;Elderly ↓ ;RD, renal impairment, Renal disease，including uremia ↓ ;Hepatic cirrhosis, cirr ↓ ;nephritic syndrome ↓ ;hypoalbuminemia Alb ↓ ;Burn ↓ ;hyperthyroid, HTh → ; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Frequency Brand Name Component Reference
Max dose for children 0.6 mg/kg 0.6 mg/kg intravenous injection, IV tid Valium diazepam PDR
Max dose for adolescents 0.6 mg/kg 0.6 mg/kg intravenous injection, IV tid Valium diazepam PDR
Max dose for adults 40.0 mg/day 40 mg/day PO, oral Valium diazepam PDR
Max dose for geriatric 40.0 mg/day 40 mg/day PO, oral Valium diazepam PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1