Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00827 ...
Drug Name Cinoxacin
Molecular Weight 262.2182
Molecular Formula C12H10N2O5
CAS Number 28657-80-9
SMILES CCN1N=C(C(O)=O)C(=O)C2=CC3=C(OCO3)C=C12
External Links
DRUGBANK DB00827
PubChem Compound 2762
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 1.5 - 1.5 - DRUGBANK
Melting Point 261.5 ℃ 261-262 ℃ White, W.A.; U.S. Patent 3,669,965; June 13, 1972; assigned to Eli Lilly & Company.

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Metabolic 35.0 % 30-40 % Liver metabolism; Inactive metabolite; DRUGBANK
Half-life 1.5 h 1.5 h elimination half-life; DRUGBANK
Half-life 10.0 h >10 h RD, renal impairment, Renal disease，including uremia; DRUGBANK
Toxicity LD50 3610.0 mg/kg 3610.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 1380.0 mg/kg 1380.0 mg/kg subcutaneous injection, SC; Rattus, Rat; DRUGBANK
Toxicity LD50 860.0 mg/kg 860.0 mg/kg intravenous injection, IV; Rattus, Rat; DRUGBANK
Toxicity LD50 2330.0 mg/kg 2330.0 mg/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 900.0 mg/kg 900.0 mg/kg subcutaneous injection, SC; mouse; DRUGBANK
Toxicity LD50 850.0 mg/kg 850.0 mg/kg intravenous injection, IV; mouse; DRUGBANK
Protein Binding 70.0 % 60-80 % DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1