Basic Information
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 3.8 | - | 3.8 | - | DRUGBANK |
| Melting Point | 197.0 | ℃ | 195-199 | ℃ | Berger, L. and Corraz, A.J.; US. Patent 3,896,145; July 22,1975; assigned to Hoffmann- LaRoche, Inc. |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 90.0 | % | >90 | % | PO, oral; | DRUGBANK |
| Clearance | 0.0306 | L/h/kg | 0.51 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.22 | L/kg | 0.22 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 8.0 | h | ~8(4.5-9.8) | h | dog; | DRUGBANK | Half-life | 9.9 | h | 9.9 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 282.0 | mg/kg | 282.0 | mg/kg | PO, oral; mouse; | DRUGBANK | Toxicity LD50 | 149.0 | mg/kg | 149.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK |
| Protein Binding | 99.0 | % | 99 | % | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1