Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00819 ...
Drug Name Acetazolamide
Molecular Weight 222.245
Molecular Formula C4H6N4O3S2
CAS Number 59-66-5
SMILES CC(=O)NC1=NN=C(S1)S(N)(=O)=O
External Links
DRUGBANK DB00819
PubChem Compound 1986
PDR 649
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P -0.26 - -0.26 - HANSCH,C ET AL. (1995)
Melting Point 260.5 ℃ 260.5 ℃ PhysProp
Water Solubility 980.0 mg/L 980 mg/L YALKOWSKY,SH & DANNENFELSER,RM 1992)
pKa 7.2 - 7.2 - MERCK INDEX (1996)
Log S -2.36 - -2.36 - ADME Research, USCD

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Clearance 0.0390 L/h/kg 0.65 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.37 L/kg 0.37 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 6.0 h 3-9 h DRUGBANK
Half-life 13.0 h 13 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Protein Binding 98.0 % 98 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for neonates 20.0 mg/kg/day 20 mg/kg/day intravenous injection, IV;PO, oral; Diamox Sequels acetazolamide PDR
Max dose for infants 30.0 mg/kg/day 30 mg/kg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for infants 20.0 mg/kg/day 20 mg/kg/day intravenous injection, IV;PO, oral; Diamox Sequels acetazolamide PDR
Max dose for infants 5.0 mg/kg/day 5 mg/kg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for infants 7.5 mg/kg/day 7.5 mg/kg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for infants 100.0 mg/kg/day 100 mg/kg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for children 1000.0 mg/day 1000 mg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for children 30.0 mg/kg/day 30 mg/kg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for children 1000.0 mg/day 1000 mg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for children 20.0 mg/kg/day 20 mg/kg/day intravenous injection, IV;PO, oral; Diamox Sequels acetazolamide PDR
Max dose for children 5.0 mg/kg/day 5 mg/kg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for children 250.0 mg/day 250 mg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for children 7.5 mg/kg/day 7.5 mg/kg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for children 750.0 mg/day 750 mg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for children 100.0 mg/kg/day 100 mg/kg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for children 2000.0 mg/day 2000 mg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for children 30.0 mg/kg/day 30 mg/kg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for children 1000.0 mg/day 1000 mg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for children 20.0 mg/kg/day 20 mg/kg/day intravenous injection, IV;PO, oral; Diamox Sequels acetazolamide PDR
Max dose for children 5.0 mg/kg/day 5 mg/kg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for children 250.0 mg/day 250 mg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for children 7.5 mg/kg/day 7.5 mg/kg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for children 750.0 mg/day 750 mg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for children 100.0 mg/kg/day 100 mg/kg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for children 2000.0 mg/day 2000 mg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for adolescents 1000.0 mg/day 1000 mg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for adolescents 30.0 mg/kg/day 30 mg/kg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for adolescents 1000.0 mg/day 1000 mg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for adolescents 20.0 mg/kg/day 20 mg/kg/day intravenous injection, IV;PO, oral; Diamox Sequels acetazolamide PDR
Max dose for adolescents 1000.0 mg/day 1000 mg/day intravenous injection, IV;PO, oral; Diamox Sequels acetazolamide PDR
Max dose for adolescents 5.0 mg/kg/day 5 mg/kg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for adolescents 250.0 mg/day 250 mg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for adolescents 7.5 mg/kg/day 7.5 mg/kg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for adolescents 750.0 mg/day 750 mg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for adolescents 100.0 mg/kg/day 100 mg/kg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for adolescents 2000.0 mg/day 2000 mg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for adults 1000.0 mg/day 1000 mg/day intravenous injection, IV;PO, oral; Diamox Sequels acetazolamide PDR
Max dose for adults 4000.0 mg/day 4000 mg/day PO, oral Diamox Sequels acetazolamide PDR
Max dose for geriatric 1000.0 mg/day 1000 mg/day intravenous injection, IV;PO, oral; Diamox Sequels acetazolamide PDR
Max dose for geriatric 4000.0 mg/day 4000 mg/day PO, oral Diamox Sequels acetazolamide PDR

Drug Property Radar Chart

...

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1