Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00818 ...
Drug Name Propofol
Molecular Weight 178.2707
Molecular Formula C12H18O
CAS Number 2078-54-8
SMILES CC(C)C1=CC=CC(C(C)C)=C1O
External Links
DRUGBANK DB00818
T3DB T3D2900
PubChem Compound 4943
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 3.79 - 3.79 - HANSCH,C ET AL. (1995)
Boiling Point 256.0 ℃ 256 ℃ PhysProp
Melting Point 18.0 ℃ 18 ℃ PhysProp
Water Solubility 124.0 mg/L 124 mg/L DRUGBANK
pKa 11.1 - 11.1 - SERJEANT,EP & DEMPSEY,B (1979)

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
C Max 3500.0 ng/ml 3.5±0.06 mcg/ml intravenous injection, IV; The Pharmacological Basis of Therapeutics
C Max 1100.0 ng/ml 1.1±0.4 mcg/ml PO, oral; patients; The Pharmacological Basis of Therapeutics
Clearance 2.2 L/h/kg 23-50 ml/kg/min DRUGBANK
Clearance 150.0 L/h 1.6-3.4 L/min adults; DRUGBANK
Clearance 1.6 L/h/kg 27±5 ml/min/kg surgery; normal,healthy; metabolism of ugt; Children ↑ ;Elderly ↓ ;hepatopathy，LD → ; The Pharmacological Basis of Therapeutics
Clearance 2.2 L/h/kg 36 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 60.0 L/kg 60.0 L/kg normal,healthy; adults; DRUGBANK
Volume of Distribution 1.7 L/kg 1.7±0.7 L/kg Apparent volume of distribution; surgery; normal,healthy; metabolism of ugt; Children ↑ ;Elderly ↓ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 4.7 L/kg 4.7 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 0.0942 h 1.8-9.5 min distribution half-life; DRUGBANK
Half-life 0.76 h 21-70 min elimination half-life; DRUGBANK
Half-life 16.3 h 1.5-31 h elimination half-life; DRUGBANK
Half-life 3.5 h 3.5±1.2 h The Pharmacological Basis of Therapeutics
Half-life 3.2 h 3.2 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 53.0 mg/kg 53.0 mg/kg intravenous injection, IV; mouse; DRUGBANK
Toxicity LD50 42.0 mg/kg 42.0 mg/kg intravenous injection, IV; Rattus, Rat; DRUGBANK
Toxicity LD50 1230.0 mg/kg 1230.0 mg/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 600.0 mg/kg 600.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 53.0 mg/kg 53.0 mg/kg intravenous injection, IV; mouse; T3DB
Toxicity LD50 42.0 mg/kg 42.0 mg/kg intravenous injection, IV; Rattus, Rat; T3DB
Toxicity LD50 1230.0 mg/kg 1230.0 mg/kg PO, oral; mouse; T3DB
Toxicity LD50 600.0 mg/kg 600.0 mg/kg PO, oral; Rattus, Rat; T3DB
Protein Binding 97.0 % 95-99 % DRUGBANK
Protein Binding 98.6 % 98.3-98.8 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1