Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00813 ...
Drug Name Fentanyl
Molecular Weight 336.4705
Molecular Formula C22H28N2O
CAS Number 437-38-7
SMILES CCC(=O)N(C1CCN(CCC2=CC=CC=C2)CC1)C1=CC=CC=C1
External Links
DRUGBANK DB00813
T3DB T3D2898
PubChem Compound 3345
PDR 1395
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 4.05 - 4.05 - SANGSTER (1993)
Melting Point 83.5 ℃ 83-84 ℃ US. Patent 3,141,823.
Water Solubility 740.0 mg/L 0.74 mg/ml https://www.ncbi.nlm.nih.gov/pubmed/2569731
pKa 8.99 - 8.99 - https://www.ncbi.nlm.nih.gov/pubmed/2569731

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
AUC 2.9 ng.h/ml 172±96 ng.min/ml Tablet, PO, oral; DRUGBANK
AUC 25.1 ng.h/ml 1508±1360 ng.min/ml Tablet, PO, oral; DRUGBANK
AUC 1.3 ng.h/ml 1.25±0.67 ng.h/ml sublingual; DRUGBANK
AUC 10.4 ng.h/ml 10.38±3.70 ng.h/ml sublingual; increasing doses; increasing doses ↓ ; DRUGBANK
AUC 0.42 ng.h/ml 0.42±0.35 ng.h/ml Transdermal preparations; DRUGBANK
AUC 3.8 ng.h/ml 3772.0 pg.h/ml nasal spray; DRUGBANK
AUC 3.8 ng.h/ml 3772.0 pg.h/ml DRUGBANK
Bioavailability 54.0 % 54 % sublingual; DRUGBANK
Bioavailability 50.0 % 50 % Tablet, PO, oral; DRUGBANK
Bioavailability 65.0 % 65 % buccal; DRUGBANK
Bioavailability 76.0 % 76 % sublingual; DRUGBANK
Bioavailability 82.0 % 82 % nasal spray; DRUGBANK
Bioavailability 50.0 % ~50 % buccal; The Pharmacological Basis of Therapeutics
C Max 0.40 ng/ml 0.4±0.1 ng/ml Tablet, PO, oral; DRUGBANK
C Max 0.20 ng/ml 0.20±0.06 ng/ml sublingual; DRUGBANK
C Max 1.6 ng/ml 1.61±0.60 ng/ml sublingual; increasing doses; increasing doses ↓ ; DRUGBANK
C Max 0.24 ng/ml 0.24±0.20 ng/ml Transdermal preparations; DRUGBANK
C Max 0.82 ng/ml 815±301 pg/ml nasal spray; DRUGBANK
C Max 0.82 ng/ml 815±301 pg/ml DRUGBANK
C Max 0.80 ng/ml 0.8±0.3 ng/ml buccal; The Pharmacological Basis of Therapeutics
C Max 1.4 ng/ml 1.4±0.5 ng/ml Transdermal preparations; The Pharmacological Basis of Therapeutics
T Max 0.50 h 20-40 min Tablet, PO, oral; DRUGBANK
T Max 0.97 h 0.69-1.25 h sublingual; increasing doses; increasing doses ↓ ; DRUGBANK
T Max 3.6 h 3.6±1.3 h Transdermal preparations; DRUGBANK
T Max 1.0 h <1 h nasal spray; DRUGBANK
T Max 1.0 h <1 h DRUGBANK
T Max 0.40 h 0.4(0.3-6) h buccal; The Pharmacological Basis of Therapeutics
T Max 35.0 h 35±15 h Transdermal preparations; The Pharmacological Basis of Therapeutics
Clearance 0.50 L/h/kg 0.5(0.3-0.7) L/h/kg Plasma clearance; DRUGBANK
Clearance 51.0 L/h 27-75 L/h intravenous injection, IV; patients; DRUGBANK
Clearance 41.5 L/h 3-80 L/h hepatopathy，LD; DRUGBANK
Clearance 54.0 L/h 30-78 L/h RD, renal impairment, Renal disease，including uremia; DRUGBANK
Clearance 0.78 L/h/kg 13±2 ml/min/kg hydrolysis; Neonates ↓ ;Children ↓ ;Elderly ↓ ;Prem, premature ↓ ; The Pharmacological Basis of Therapeutics
Clearance 0.28 L/h/kg 4.7 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 5.5 L/kg 3.0-8 L/kg intravenous injection, IV; DRUGBANK
Volume of Distribution 25.4 L/kg 25.4 L/kg PO, oral; DRUGBANK
Volume of Distribution 4.4 L/kg 0.8-8 L/kg intravenous injection, IV; hepatopathy，LD; patients; DRUGBANK
Volume of Distribution 4.0 L/kg 4.0±0.4 L/kg The Pharmacological Basis of Therapeutics
Volume of Distribution 0.89 L/kg 0.89 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 7.0 h 7 h DRUGBANK
Half-life 8.5 h 5-12 h sublingual; DRUGBANK
Half-life 3.7 h 3.7±0.4 h Prem, premature ↑ ;Children → ;CPBS ↑ ;Age ↑ ; The Pharmacological Basis of Therapeutics
Half-life 3.0 h 3 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 2.9 mg/kg 2.91 mg/kg intravenous injection, IV; Rattus, Rat; DRUGBANK
Toxicity LD50 18.0 mg/kg 18.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 368.0 mg/kg 368.0 mg/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 3.1 mg/kg 3.1 mg/kg Rattus, Rat; T3DB
Toxicity LD50 0.0300 mg/kg 0.03 mg/kg monkey; T3DB
Eliminate Route 75.0 % 75 % Urinary excretion; DRUGBANK
Eliminate Route 9.0 % 9 % Faeces excretion; DRUGBANK
Eliminate Route 5.3 % <5.3 % Urinary excretion; Unchanged drug; DRUGBANK
Eliminate Route 0.0900 % 0.09 % Faeces excretion; Unchanged drug; DRUGBANK
Eliminate Route 8.0 % 8 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 82.5 % 80-85 % plasma proteins; DRUGBANK
Protein Binding 77.9 % 77.9±1.1 % human, homo sapiens; DRUGBANK
Protein Binding 12.0 % 12±5.4 % human, homo sapiens; DRUGBANK
Protein Binding 84.0 % 84±2 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adolescents 4.0 units/day 4 units/day Transdermal preparations Abstral fentanyl PDR
Max dose for adults 4.0 dose/day 4 dose/day Transdermal preparations Abstral fentanyl PDR
Max dose for adults 800.0 mcg/dose 800 mcg/dose Abstral fentanyl PDR
Max dose for adults 2.0 dose 2 dose Abstral fentanyl PDR
Max dose for adults 4.0 treated episodes/day 4 treated episodes/day Abstral fentanyl PDR
Max dose for adults 800.0 mcg/dose 800 mcg/dose inhalation, IH Abstral fentanyl PDR
Max dose for adults 4.0 dose/day 4 dose/day inhalation, IH Abstral fentanyl PDR
Max dose for adults 40.0 mcg/dose 40 mcg/dose Abstral fentanyl PDR
Max dose for adults 80.0 dose/day 80 dose/day Abstral fentanyl PDR
Max dose for geriatric 4.0 dose/day 4 dose/day Transdermal preparations Abstral fentanyl PDR
Max dose for geriatric 800.0 mcg/dose 800 mcg/dose Abstral fentanyl PDR
Max dose for geriatric 2.0 dose 2 dose Abstral fentanyl PDR
Max dose for geriatric 4.0 treated episodes/day 4 treated episodes/day Abstral fentanyl PDR
Max dose for geriatric 800.0 mcg/dose 800 mcg/dose inhalation, IH Abstral fentanyl PDR
Max dose for geriatric 4.0 dose/day 4 dose/day inhalation, IH Abstral fentanyl PDR
Max dose for geriatric 40.0 mcg/dose 40 mcg/dose Abstral fentanyl PDR
Max dose for geriatric 80.0 dose/day 80 dose/day Abstral fentanyl PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1