Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00811 ...
Drug Name Ribavirin
Molecular Weight 244.2047
Molecular Formula C8H12N4O5
CAS Number 36791-04-5
SMILES NC(=O)C1=NN(C=N1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
External Links
DRUGBANK DB00811
PubChem Compound 37542
PDR 2443
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P -1.85 - -1.85 - MSDS
Melting Point 175.0 ℃ 174-176 ℃ MSDS

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 64.0 % 64 % Oral single dose; DRUGBANK
Bioavailability 45.0 % 45±5 % PO, oral; Male, men; AIDS,HIV; The Pharmacological Basis of Therapeutics
C Max 3687491.0 ng/ml 15.1±12.8 mM PO, oral; adults; HCV-positive; The Pharmacological Basis of Therapeutics
C Max 2710672.2 ng/ml 11.1±1.2 mM Capsule, PO, Oral; adults; AIDS,HIV; The Pharmacological Basis of Therapeutics
T Max 2.0 h 2 h PO, oral; DRUGBANK
T Max 3.0 h 3±1.8 h PO, oral; adults; HCV-positive; The Pharmacological Basis of Therapeutics
Clearance 26.0 L/h 26.0 L/h Total clearance; Oral single dose; DRUGBANK
Clearance 0.30 L/h/kg 5.0±1.0 ml/min/kg asymptomatic HIV-positive; Male, men; The Pharmacological Basis of Therapeutics
Clearance 0.31 L/h/kg 5.2 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 9.3 L/kg 9.3±1.5 L/kg asymptomatic HIV-positive; Male, men; The Pharmacological Basis of Therapeutics
Volume of Distribution 14.0 L/kg 14 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 145.0 h ~120-170 h terminal half-life; Oral single dose; DRUGBANK
Half-life 28.0 h 28±7 h Oral multiple dose; The Pharmacological Basis of Therapeutics
Half-life 150.0 h 150±5 h terminal half-life; The Pharmacological Basis of Therapeutics
Half-life 45.0 h 45 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 2700.0 mg/kg 2700.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 1300.0 mg/kg 1300.0 mg/kg Intraperitoneal, IP; mouse; DRUGBANK
Eliminate Route 61.0 % ~61 % Urinary excretion; PO, oral; DRUGBANK
Eliminate Route 12.0 % ~12 % Faeces excretion; PO, oral; DRUGBANK
Eliminate Route 17.0 % 17 % PO, oral; Unchanged drug; DRUGBANK
Eliminate Route 35.0 % 35±8 % Urinary excretion; Male, men; asymptomatic HIV-positive; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 0 % 0 % Male, men; asymptomatic HIV-positive; human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1