Basic Information
| Drug ID | DDPD00806 |
|
| Drug Name | Pentoxifylline | |
| Molecular Weight | 278.307 | |
| Molecular Formula | C13H18N4O3 | |
| CAS Number | 6493-05-6 | |
| SMILES | CN1C=NC2=C1C(=O)N(CCCCC(C)=O)C(=O)N2C | |
| External Links | ||
| DRUGBANK | DB00806 | |
| PubChem Compound | 4740 | |
| PDR | 3603 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 0.29 | - | 0.29 | - | BIOBYTE (1995) |
| Melting Point | 105.0 | ℃ | 105 | ℃ | DRUGBANK |
| Water Solubility | 77000.0 | mg/L | 77000 | mg/L | MERCK INDEX 1996) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 2.3 | L/h/kg | 39 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 1.8 | L/kg | 1.8 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 0.60 | h | 0.4-0.8 | h | DRUGBANK | Half-life | 1.2 | h | 1.2 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 1385.0 | mg/kg | 1385.0 | mg/kg | PO, oral; mouse; | DRUGBANK |
| Protein Binding | 70.0 | % | 70 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 20.0 | mg/kg/day | 20 | mg/kg/day | PO, oral | Pentoxifylline | pentoxifylline | PDR |
| Max dose for adults | 1200.0 | mg/day | 1200 | mg/day | PO, oral | Pentoxifylline | pentoxifylline | PDR |
| Max dose for adults | 2400.0 | mg/day | 2400 | mg/day | PO, oral | Pentoxifylline | pentoxifylline | PDR |
| Max dose for elderly | 1200.0 | mg/day | 1200 | mg/day | PO, oral | Pentoxifylline | pentoxifylline | PDR |
| Max dose for elderly | 2400.0 | mg/day | 2400 | mg/day | PO, oral | Pentoxifylline | pentoxifylline | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1