Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00802 ...
Drug Name Alfentanil
Molecular Weight 416.5172
Molecular Formula C21H32N6O3
CAS Number 71195-58-9
SMILES CCN1N=NN(CCN2CCC(COC)(CC2)N(C(=O)CC)C2=CC=CC=C2)C1=O
External Links
DRUGBANK DB00802
T3DB T3D2894
PubChem Compound 51263
PDR 673

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.16 - 2.16 - HANSCH,C ET AL. (1995)
Melting Point 140.8 ℃ 140.8 ℃ Janssens, F.; US. Patent 4,167,574; September 11, 1979; assigned to Janssen Pharmaceutica NV.
Water Solubility 34.6 mg/L 34.6 mg/L DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
C Max 150.0 ng/ml 100-200 ng/ml The Pharmacological Basis of Therapeutics
C Max 325.0 ng/ml 310-340 ng/ml The Pharmacological Basis of Therapeutics
Clearance 0.30 L/h/kg 5.0 ml/min/kg DRUGBANK
Clearance 0.40 L/h/kg 6.7±2.4 ml/min/kg hydrolysis; Elderly ↓ ;Hepatitis, Hep ↓ ;CPBS → ; The Pharmacological Basis of Therapeutics
Clearance 0.23 L/h/kg 3.9 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.57 L/kg 0.4-1 L/kg DRUGBANK
Volume of Distribution 0.80 L/kg 0.8±0.3 L/kg Elderly → ;Hepatitis, Hep ↓ ;CPBS ↑ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.45 L/kg 0.45 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 1.7 h 90-111 min DRUGBANK
Half-life 1.6 h 1.6±0.2 h Hepatic cirrhosis, cirr ↑ ;CPBS ↑ ;Age ↑ ; The Pharmacological Basis of Therapeutics
Half-life 1.6 h 1.6 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 1.0 % 1 % Unchanged drug; DRUGBANK
Eliminate Route 1.0 % <1 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 92.0 % 92 % DRUGBANK
Protein Binding 92.0 % 92±2 % Hepatic cirrhosis, cirr ↓ ; The Pharmacological Basis of Therapeutics

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1