Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00798 ...
Drug Name Gentamicin
Molecular Weight 477.5954
Molecular Formula C21H43N5O7
CAS Number 1403-66-3
SMILES CNC(C)C1CCC(N)C(OC2C(N)CC(N)C(OC3OCC(C)(O)C(NC)C3O)C2O)O1
External Links
DRUGBANK DB00798
PubChem Compound 3467
PDR 1562
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P -3.1 - -3.1 - DRUGBANK
Melting Point 105.0 ℃ 105 ℃ PhysProp
Water Solubility 100000.0 mg/L 100 mg/ml DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 100.0 % ~100 % IM,intramuscular injection; The Pharmacological Basis of Therapeutics
C Max 5000.0 ng/ml 5.0±0.4 mcg/ml intravenous injection, IV; adults; normal,healthy; The Pharmacological Basis of Therapeutics
C Max 4900.0 ng/ml 4.9±0.5 mcg/ml intravenous infusion, IV in drop; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 0.53 h 0.3-0.75 h intravenous injection, IV; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 1.0 h 1.0 h intravenous infusion, IV in drop; adults; normal,healthy; The Pharmacological Basis of Therapeutics
Clearance 0.0600 L/h/kg 1 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.31 L/kg 0.31±0.10 L/kg Neonates ↑ ;Children → ;Elderly → ;RD, renal impairment, Renal disease，including uremia → ;Obesity ↓ ;Cystic fibrosis → ; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.33 L/kg 0.33 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 1.3 h 3-3½ h Infants; DRUGBANK
Half-life 2.2 h 5½ h Neonates; Prem, premature; DRUGBANK
Half-life 2.5 h 2-3 h The Pharmacological Basis of Therapeutics
Half-life 53.0 h 53±25 h terminal half-life; The Pharmacological Basis of Therapeutics
Half-life 4.7 h 4.7 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 52.0 mg/kg 52.0 mg/kg intravenous injection, IV; mouse; DRUGBANK
Toxicity LD50 96.0 mg/kg 96.0 mg/kg intravenous injection, IV; Rattus, Rat; DRUGBANK
Eliminate Route 90.0 % >90 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 15.0 % 0-30 % DRUGBANK
Protein Binding 10.0 % <10 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for neonates 7.5 mg/kg/day 7.5 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Gentamicin Sulfate Ointment gentamicin sulfate PDR
Max dose for neonates 5.0 mg/kg/day 5 mg/kg/dose intravenous injection, IV;IM,intramuscular injection; Gentamicin Sulfate Ointment gentamicin sulfate PDR
Max dose for neonates 10.0 mg/kg/day 5 mg/kg/dose intravenous injection, IV;IM,intramuscular injection; Gentamicin Sulfate Ointment gentamicin sulfate PDR
Max dose for neonates 4.5 mg/kg/day 4.5 mg/kg/dose/day intravenous injection, IV;IM,intramuscular injection; Gentamicin Sulfate Ointment gentamicin sulfate PDR
Max dose for infants 7.5 mg/kg/day 7.5 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Gentamicin Sulfate Ointment gentamicin sulfate PDR
Max dose for children 7.5 mg/kg/day 7.5 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Gentamicin Sulfate Ointment gentamicin sulfate PDR
Max dose for adolescents 7.5 mg/kg/day 7.5 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Gentamicin Sulfate Ointment gentamicin sulfate PDR
Max dose for adults 5.0 mg/kg/day 5 mg/kg/day PO, oral;intravenous injection, IV; Gentamicin Sulfate Ointment gentamicin sulfate PDR
Max dose for adults 7.0 mg/kg/day 7 mg/kg/day intravenous injection, IV Gentamicin Sulfate Ointment gentamicin sulfate PDR
Max dose for geriatric 5.0 mg/kg/day 5 mg/kg/day PO, oral;intravenous injection, IV; Gentamicin Sulfate Ointment gentamicin sulfate PDR
Max dose for geriatric 7.0 mg/kg/day 7 mg/kg/day intravenous injection, IV Gentamicin Sulfate Ointment gentamicin sulfate PDR
Max dose for neonates 7.5 mg/kg/day 7.5 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Gentamicin Injection 40 mg/mL gentamicin sulfate PDR
Max dose for neonates 5.0 mg/kg/day 5 mg/kg/dose intravenous injection, IV;IM,intramuscular injection; Gentamicin Injection 40 mg/mL gentamicin sulfate PDR
Max dose for neonates 10.0 mg/kg/day 5 mg/kg/dose intravenous injection, IV;IM,intramuscular injection; Gentamicin Injection 40 mg/mL gentamicin sulfate PDR
Max dose for neonates 4.5 mg/kg/day 4.5 mg/kg/dose/day intravenous injection, IV;IM,intramuscular injection; Gentamicin Injection 40 mg/mL gentamicin sulfate PDR
Max dose for infants 7.5 mg/kg/day 7.5 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Gentamicin Injection 40 mg/mL gentamicin sulfate PDR
Max dose for children 7.5 mg/kg/day 7.5 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Gentamicin Injection 40 mg/mL gentamicin sulfate PDR
Max dose for adolescents 7.5 mg/kg/day 7.5 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Gentamicin Injection 40 mg/mL gentamicin sulfate PDR
Max dose for adults 5.0 mg/kg/day 5 mg/kg/day PO, oral;intravenous injection, IV; Gentamicin Injection 40 mg/mL gentamicin sulfate PDR
Max dose for adults 7.0 mg/kg/day 7 mg/kg/day intravenous injection, IV Gentamicin Injection 40 mg/mL gentamicin sulfate PDR
Max dose for geriatric 5.0 mg/kg/day 5 mg/kg/day PO, oral;intravenous injection, IV; Gentamicin Injection 40 mg/mL gentamicin sulfate PDR
Max dose for geriatric 7.0 mg/kg/day 7 mg/kg/day intravenous injection, IV Gentamicin Injection 40 mg/mL gentamicin sulfate PDR
Max dose for neonates 7.5 mg/kg/day 7.5 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Gentamicin Injection 10 mg/mL gentamicin sulfate PDR
Max dose for neonates 5.0 mg/kg/day 5 mg/kg/dose intravenous injection, IV;IM,intramuscular injection; Gentamicin Injection 10 mg/mL gentamicin sulfate PDR
Max dose for neonates 10.0 mg/kg/day 5 mg/kg/dose intravenous injection, IV;IM,intramuscular injection; Gentamicin Injection 10 mg/mL gentamicin sulfate PDR
Max dose for neonates 4.5 mg/kg/day 4.5 mg/kg/dose/day intravenous injection, IV;IM,intramuscular injection; Gentamicin Injection 10 mg/mL gentamicin sulfate PDR
Max dose for infants 7.5 mg/kg/day 7.5 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Gentamicin Injection 10 mg/mL gentamicin sulfate PDR
Max dose for children 7.5 mg/kg/day 7.5 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Gentamicin Injection 10 mg/mL gentamicin sulfate PDR
Max dose for adolescents 7.5 mg/kg/day 7.5 mg/kg/day intravenous injection, IV;IM,intramuscular injection; Gentamicin Injection 10 mg/mL gentamicin sulfate PDR
Max dose for adults 5.0 mg/kg/day 5 mg/kg/day PO, oral;intravenous injection, IV; Gentamicin Injection 10 mg/mL gentamicin sulfate PDR
Max dose for adults 7.0 mg/kg/day 7 mg/kg/day intravenous injection, IV Gentamicin Injection 10 mg/mL gentamicin sulfate PDR
Max dose for geriatric 5.0 mg/kg/day 5 mg/kg/day PO, oral;intravenous injection, IV; Gentamicin Injection 10 mg/mL gentamicin sulfate PDR
Max dose for geriatric 7.0 mg/kg/day 7 mg/kg/day intravenous injection, IV Gentamicin Injection 10 mg/mL gentamicin sulfate PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1