Basic Information
| Drug ID | DDPD00796 |
|
| Drug Name | Candesartan cilexetil | |
| Molecular Weight | 610.671 | |
| Molecular Formula | C33H34N6O6 | |
| CAS Number | 145040-37-5 | |
| SMILES | CCOC1=NC2=C(N1CC1=CC=C(C=C1)C1=CC=CC=C1C1=NN=NN1)C(=CC=C2)C(=O)OC(C)OC(=O)OC1CCCCC1 | |
| External Links | ||
| DRUGBANK | DB00796 | |
| PubChem Compound | 2540 | |
| PDR | 2314 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 6.1 | - | 6.1 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 15.0 | % | 15 | % | PO, oral; | DRUGBANK |
| Clearance | 0.0222 | L/h/kg | 0.37 | ml/min/kg | DRUGBANK | |
| Volume of Distribution | 0.13 | L/kg | 0.13 | L/kg | DRUGBANK | |
| Half-life | 9.0 | h | ~9 | h | DRUGBANK | |
| Toxicity LDLo | 1500.0 | mg/kg | 1000-2000 | mg/kg | Single dose; Metabolite; mouse; | DRUGBANK |
| Eliminate Route | 26.0 | % | ~26 | % | Urinary excretion; PO, oral; Unchanged drug; | DRUGBANK |
| Protein Binding | 99.0 | % | >99 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 32.0 | mg/day | 32 | mg/day | PO, oral | Atacand | candesartan cilexetil | PDR |
| Max dose for children | 16.0 | mg/day | 16 | mg/day | PO, oral | Atacand | candesartan cilexetil | PDR |
| Max dose for children | 0.4 | mg/kg/day | 0.4 | mg/kg/day | PO, oral | Atacand | candesartan cilexetil | PDR |
| Max dose for adolescents | 32.0 | mg/day | 32 | mg/day | PO, oral | Atacand | candesartan cilexetil | PDR |
| Max dose for adolescents | 16.0 | mg/day | 16 | mg/day | PO, oral | Atacand | candesartan cilexetil | PDR |
| Max dose for adults | 32.0 | mg/day | 32 | mg/day | PO, oral | Atacand | candesartan cilexetil | PDR |
| Max dose for elderly | 32.0 | mg/day | 32 | mg/day | PO, oral | Atacand | candesartan cilexetil | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1