Basic Information
| Drug ID | DDPD00795 |
|
| Drug Name | Sulfasalazine | |
| Molecular Weight | 398.393 | |
| Molecular Formula | C18H14N4O5S | |
| CAS Number | 599-79-1 | |
| SMILES | OC(=O)C1=CC(=CC=C1O)\N=N\C1=CC=C(C=C1)S(=O)(=O)NC1=NC=CC=C1 | |
| External Links | ||
| DRUGBANK | DB00795 | |
| T3DB | T3D2892 | |
| PubChem Compound | 5359476 | |
| PDR | 1020 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Caco-2 Permeability | -6.33 | - | -6.33 | - | ADME Research, USCD |
| Log P | 2.5 | - | 2.5 | - | DRUGBANK |
| Melting Point | 220.0 | ℃ | 220 | ℃ | PhysProp |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 1.0 | L/h | 1.0 | L/h | intravenous injection, IV; | DRUGBANK | Clearance | 0.0156 | L/h/kg | 0.26 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 7.5 | L | 7.5±1.6 | L | DRUGBANK | Volume of Distribution | 0.11 | L/kg | 0.11 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 7.5 | h | 5-10 | h | DRUGBANK | Half-life | 7.6 | h | 7.6 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 60.0 | mg/kg/day | 60 | mg/kg/day | PO, oral | Azulfidine EN-tabs | sulfasalazine | PDR |
| Max dose for children | 4000.0 | mg/day | 4 | g/day | PO, oral | Azulfidine EN-tabs | sulfasalazine | PDR |
| Max dose for children | 30.0 | mg/kg/day | 30 | mg/kg/day | PO, oral | Azulfidine EN-tabs | sulfasalazine | PDR |
| Max dose for children | 2000.0 | mg/day | 2 | g/day | PO, oral | Azulfidine EN-tabs | sulfasalazine | PDR |
| Max dose for children | 4000.0 | mg/day | 4 | g/day | PO, oral | Azulfidine EN-tabs | sulfasalazine | PDR |
| Max dose for children | 50.0 | mg/kg/day | 50 | mg/kg/day | PO, oral | Azulfidine EN-tabs | sulfasalazine | PDR |
| Max dose for adolescents | 60.0 | mg/kg/day | 60 | mg/kg/day | PO, oral | Azulfidine EN-tabs | sulfasalazine | PDR |
| Max dose for adolescents | 4000.0 | mg/day | 4 | g/day | PO, oral | Azulfidine EN-tabs | sulfasalazine | PDR |
| Max dose for adolescents | 30.0 | mg/kg/day | 30 | mg/kg/day | PO, oral | Azulfidine EN-tabs | sulfasalazine | PDR |
| Max dose for adolescents | 2000.0 | mg/day | 2 | g/day | PO, oral | Azulfidine EN-tabs | sulfasalazine | PDR |
| Max dose for adults | 4000.0 | mg/day | 4 | g/day | PO, oral | Azulfidine EN-tabs | sulfasalazine | PDR |
| Max dose for adults | 3000.0 | mg/day | 3 | g/day | PO, oral | Azulfidine EN-tabs | sulfasalazine | PDR |
| Max dose for geriatric | 4000.0 | mg/day | 4 | g/day | PO, oral | Azulfidine EN-tabs | sulfasalazine | PDR |
| Max dose for geriatric | 3000.0 | mg/day | 3 | g/day | PO, oral | Azulfidine EN-tabs | sulfasalazine | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1