Basic Information
| Drug ID | DDPD00794 |
|
| Drug Name | Primidone | |
| Molecular Weight | 218.2518 | |
| Molecular Formula | C12H14N2O2 | |
| CAS Number | 125-33-7 | |
| SMILES | CCC1(C(=O)NCNC1=O)C1=CC=CC=C1 | |
| External Links | ||
| DRUGBANK | DB00794 | |
| PubChem Compound | 4909 | |
| PDR | 775 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 0.91 | - | 0.91 | - | HANSCH,C ET AL. (1995) |
| Melting Point | 281.5 | ℃ | 281.5 | ℃ | PhysProp |
| Water Solubility | 500.0 | mg/L | 500 | mg/L | YALKOWSKY,SH & DANNENFELSER,RM 1992) |
| Log S | -2.64 | - | -2.64 | - | ADME Research, USCD |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 80.0 | % | 80 | % | PO, oral; | DRUGBANK |
| C Max | 2700.0 | ng/ml | 2.7±0.4 | ug/ml | Oral single dose; | DRUGBANK |
| T Max | 3.0 | h | 2-4 | h | PO, oral; | DRUGBANK | T Max | 3.8 | h | 0.5-7 | h | Oral single dose; | DRUGBANK |
| Clearance | 1.8 | L/h | 30.0 | ml/min | DRUGBANK | |
| Volume of Distribution | 0.65 | L/kg | 0.5-0.8 | L/kg | DRUGBANK | |
| Half-life | 14.5 | h | 7-22 | h | adults; | DRUGBANK | Half-life | 8.0 | h | 5-11 | h | Children; | DRUGBANK | Half-life | 44.0 | h | 8-80 | h | Neonates; | DRUGBANK |
| Toxicity LD50 | 1500.0 | mg/kg | 1500.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 280.0 | mg/kg | 280.0 | mg/kg | PO, oral; mouse; | DRUGBANK | Toxicity LD50 | 240.0 | mg/kg | 240.0 | mg/kg | Intraperitoneal, IP; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 332.0 | mg/kg | 332.0 | mg/kg | Intraperitoneal, IP; mouse; | DRUGBANK |
| Eliminate Route | 76.8 | % | 72.9-80.6 | % | Urinary excretion; | DRUGBANK |
| Protein Binding | 12.2 | % | 10.78-13.7 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 25.0 | mg/kg/day | 25 | mg/kg/day | PO, oral | Mysoline | primidone | PDR |
| Max dose for infants | 2000.0 | mg/day | 2000 | mg/day | PO, oral | Mysoline | primidone | PDR |
| Max dose for infants | 25.0 | mg/kg/day | 25 | mg/kg/day | PO, oral | Mysoline | primidone | PDR |
| Max dose for infants | 1000.0 | mg/kg/day | 1000 | mg/kg/day | PO, oral | Mysoline | primidone | PDR |
| Max dose for children | 2000.0 | mg/day | 2000 | mg/day | PO, oral | Mysoline | primidone | PDR |
| Max dose for adolescents | 2000.0 | mg/day | 2000 | mg/day | PO, oral | Mysoline | primidone | PDR |
| Max dose for elderly | 2000.0 | mg/day | 2000 | mg/day | PO, oral | Mysoline | primidone | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1