Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00787 ...
Drug Name Acyclovir
Molecular Weight 225.2046
Molecular Formula C8H11N5O3
CAS Number 59277-89-3
SMILES NC1=NC(=O)C2=C(N1)N(COCCO)C=N2
External Links
DRUGBANK DB00787
PubChem Compound 2022
PDR 1341
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Caco-2 Permeability -6.15 - -6.15 - ADME Research, USCD
Log P -1.76 - -1.76 - http://www.chemspider.com/Chemical-Structure.1945.html
Boiling Point 595.0 ℃ 595 ℃ http://www.chemspider.com/Chemical-Structure.1945.html
Melting Point 255.0 ℃ 255 ℃ http://www.chemspider.com/Chemical-Structure.1945.html
Water Solubility 1410.0 mg/L 1.41 mg/ml Avaclyr Ophthalmic Ointment FDA label
pKa 2.52 - 2.52,9.35 - Avaclyr Ophthalmic Ointment FDA label
pKa 9.35 - 2.52,9.35 - DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 4.7 % <0.02-9.4 % skin/dermal; DRUGBANK
AUC 3029.6 ng.h/ml 2956.6-3102.5 ng.h/ml DRUGBANK
Bioavailability 15.0 % 10-20 % PO, oral; increasing doses; food; increasing doses ↑ ;food → ; DRUGBANK
Bioavailability 22.5 % 15-30 % PO, oral; increasing doses ↓ ; The Pharmacological Basis of Therapeutics
C Max 625.1 ng/ml 593.7-656.5 ng/ml DRUGBANK
C Max 1002160.5 ng/ml 3.5-5.4 mM Oral multiple dose; The Pharmacological Basis of Therapeutics
T Max 1.1 h 1.1±0.4 h DRUGBANK
T Max 1.8 h 1.5-2 h Oral multiple dose; The Pharmacological Basis of Therapeutics
Metabolic 15.0 % <15 % DRUGBANK
Metabolic 1.0 % 1 % DRUGBANK
Clearance 8.6 L/h/m2 248.0 ml/min/1.73m2 Renal clearance; DRUGBANK
Clearance 4.2 L/h/m2 122.0 ml/min/1.73m2 Total clearance; Neonates; DRUGBANK
Clearance 0.28 L/h/kg 4.7 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.60 L/kg 0.6 L/kg DRUGBANK
Volume of Distribution 0.69 L/kg 0.69±0.19 L/kg Neonates ↓ ;RD, renal impairment, Renal disease，including uremia → ; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.71 L/kg 0.71 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 5.0 h ~5 h elimination half-life; DRUGBANK
Half-life 2.6 h 2.6 h Children; DRUGBANK
Half-life 2.4 h 2.4±0.7 h Neonates ↑ ;Children → ;RD, renal impairment, Renal disease，including uremia ↑ ; The Pharmacological Basis of Therapeutics
Half-life 2.5 h 2.5 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 0.10 % <0.1 % lung excretion; DRUGBANK
Eliminate Route 2.0 % <2 % Faeces excretion; DRUGBANK
Eliminate Route 91.0 % 90-92 % Unchanged drug; DRUGBANK
Eliminate Route 75.0 % 75±10 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 21.0 % 9-33 % plasma proteins; DRUGBANK
Protein Binding 15.0 % 15±4 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for neonates 60.0 mg/kg/day 60 mg/kg/day intravenous injection, IV Zovirax Ointment acyclovir PDR
Max dose for neonates 900.0 mg/m2/day 900 mg/m2/day PO, oral Zovirax Ointment acyclovir PDR
Max dose for infants 60.0 mg/kg/day 60 mg/kg/day intravenous injection, IV Zovirax Ointment acyclovir PDR
Max dose for infants 80.0 mg/kg/day 80 mg/kg/day PO, oral Zovirax Ointment acyclovir PDR
Max dose for children 30.0 mg/kg/day 30 mg/kg/day intravenous injection, IV Zovirax Ointment acyclovir PDR
Max dose for children 45.0 mg/kg/day 45 mg/kg/day intravenous injection, IV Zovirax Ointment acyclovir PDR
Max dose for children 80.0 mg/kg/day 80 mg/kg/day PO, oral Zovirax Ointment acyclovir PDR
Max dose for children 3200.0 mg/day 3200 mg/day PO, oral Zovirax Ointment acyclovir PDR
Max dose for children 4000.0 mg/day 4000 mg/day Zovirax Ointment acyclovir PDR
Max dose for children 60.0 mg/kg/day 60 mg/kg/day intravenous injection, IV Zovirax Ointment acyclovir PDR
Max dose for children 80.0 mg/kg/day 80 mg/kg/day PO, oral Zovirax Ointment acyclovir PDR
Max dose for children 3200.0 mg/day 3200 mg/day PO, oral Zovirax Ointment acyclovir PDR
Max dose for children 60.0 mg/kg/day 60 mg/kg/day intravenous injection, IV Zovirax Ointment acyclovir PDR
Max dose for children 80.0 mg/kg/day 80 mg/kg/day PO, oral Zovirax Ointment acyclovir PDR
Max dose for adolescents 30.0 mg/kg/day 30 mg/kg/day intravenous injection, IV Zovirax Ointment acyclovir PDR
Max dose for adolescents 45.0 mg/kg/day 45 mg/kg/day intravenous injection, IV Zovirax Ointment acyclovir PDR
Max dose for adolescents 80.0 mg/kg/day 80 mg/kg/day PO, oral Zovirax Ointment acyclovir PDR
Max dose for adolescents 3200.0 mg/day 3200 mg/day PO, oral Zovirax Ointment acyclovir PDR
Max dose for adolescents 4000.0 mg/day 4000 mg/day Zovirax Ointment acyclovir PDR
Max dose for adults 30.0 mg/kg/day 30 mg/kg/day intravenous injection, IV Zovirax Ointment acyclovir PDR
Max dose for adults 45.0 mg/kg/day 45 mg/kg/day intravenous injection, IV Zovirax Ointment acyclovir PDR
Max dose for adults 4000.0 mg/day 4000 mg/day PO, oral Zovirax Ointment acyclovir PDR
Max dose for adults 50.0 mg/dose 50 mg/dose buccal tablets Zovirax Ointment acyclovir PDR
Max dose for geriatric 30.0 mg/kg/day 30 mg/kg/day intravenous injection, IV Zovirax Ointment acyclovir PDR
Max dose for geriatric 45.0 mg/kg/day 45 mg/kg/day intravenous injection, IV Zovirax Ointment acyclovir PDR
Max dose for geriatric 4000.0 mg/day 4000 mg/day PO, oral Zovirax Ointment acyclovir PDR
Max dose for geriatric 50.0 mg/dose 50 mg/dose buccal tablets Zovirax Ointment acyclovir PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1