Basic Information
| Drug ID | DDPD00784 |
|
| Drug Name | Mefenamic acid | |
| Molecular Weight | 241.2851 | |
| Molecular Formula | C15H15NO2 | |
| CAS Number | 61-68-7 | |
| SMILES | CC1=C(C)C(NC2=CC=CC=C2C(O)=O)=CC=C1 | |
| External Links | ||
| DRUGBANK | DB00784 | |
| PubChem Compound | 4044 | |
| PDR | 1925 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 5.12 | - | 5.12 | - | HANSCH,C ET AL. (1995) |
| Melting Point | 230.5 | ℃ | 230-231 | ℃ | PhysProp |
| Water Solubility | 20.0 | mg/L | 20 | mg/L | YALKOWSKY,SH & DANNENFELSER,RM 1992) |
| pKa | 4.2 | - | 4.2 | - | SANGSTER (1994) |
| Log S | -3.78 | - | -3.78 | - | ADME Research, USCD |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 21.2 | L/h | 21.23 | L/h | PO, oral; normal,healthy; adults; | DRUGBANK |
| Volume of Distribution | 1.1 | L/kg | 1.06 | L/kg | normal,healthy; adults; | DRUGBANK |
| Half-life | 2.0 | h | 2 | h | DRUGBANK | |
| Toxicity LD50 | 740.0 | mg/kg | 740.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK |
| Eliminate Route | 20.0 | % | 20 | % | DRUGBANK | |
| Protein Binding | 90.0 | % | 90 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adolescents | 1250.0 | mg/day | 1250 | mg/day | PO, oral | Ponstel | mefenamic acid | PDR |
| Max dose for adults | 1250.0 | mg/day | 1250 | mg/day | PO, oral | Ponstel | mefenamic acid | PDR |
| Max dose for elderly | 1250.0 | mg/day | 1250 | mg/day | PO, oral | Ponstel | mefenamic acid | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1