Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00781 ...
Drug Name Polymyxin B
Molecular Weight 1203.499
Molecular Formula C56H98N16O13
CAS Number 1404-26-8
SMILES [H][C@]1(NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@@H](CCN)NC(=O)[C@H](CCNC1=O)NC(=O)[C@H](CCN)NC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)CCCCC(C)CC)[C@@H](C)O)[C@@H](C)O
External Links
DRUGBANK DB00781
T3DB T3D3529
PDR 3657

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Melting Point 203.0 ℃ >203 ℃ MSDS
pKa 8.9 - 8.9 - https://www.chemicalbook.com/ChemicalProductProperty_US_CB8666707.aspx

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Absorption 0 % 0 % PO, oral; DRUGBANK
Metabolic 1.0 % <1 % Urinary excretion; DRUGBANK
Clearance 2.4 L/h 2.37-2.5 L/h DRUGBANK
Volume of Distribution 40.8 L 34.3-47.2 L DRUGBANK
Half-life 10.3 h 9-11.5 h DRUGBANK
Half-life 6.0 h 6 h different study; DRUGBANK
Half-life 60.0 h 48-72 h different study; renal insufficiency; DRUGBANK
Eliminate Route 60.0 % 60 % Urinary excretion; DRUGBANK
Protein Binding 85.5 % 79-92 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for neonates 45000.0 units/kg/day 45000 units/kg/day IM,intramuscular injection Polymyxin B polymyxin B sulfate PDR
Max dose for infants 40000.0 units/kg/day 40000 units/kg/day IM,intramuscular injection;intravenous injection, IV; Polymyxin B polymyxin B sulfate PDR
Max dose for infants 20000.0 units/day 20000 units/day intrathecal administration Polymyxin B polymyxin B sulfate PDR
Max dose for infants 100000.0 units/day 100000 units/day ophthalmic administration Polymyxin B polymyxin B sulfate PDR
Max dose for infants 25000.0 units/kg/day 25000 units/kg/day ophthalmic administration;total systemic; Polymyxin B polymyxin B sulfate PDR
Max dose for children 25000.0 units/kg/day 25000 units/kg/day intravenous injection, IV Polymyxin B polymyxin B sulfate PDR
Max dose for children 30000.0 units/kg/day 30000 units/kg/day IM,intramuscular injection Polymyxin B polymyxin B sulfate PDR
Max dose for children 100000.0 units/day 100000 units/day ophthalmic administration Polymyxin B polymyxin B sulfate PDR
Max dose for children 50000.0 units/day 50000 units/day intrathecal administration Polymyxin B polymyxin B sulfate PDR
Max dose for children 25000.0 units/kg/day 25000 units/kg/day ophthalmic administration;total systemic; Polymyxin B polymyxin B sulfate PDR
Max dose for children 25000.0 units/kg/day 25000 units/kg/day intravenous injection, IV Polymyxin B polymyxin B sulfate PDR
Max dose for children 30000.0 units/kg/day 30000 units/kg/day IM,intramuscular injection Polymyxin B polymyxin B sulfate PDR
Max dose for children 100000.0 units/day 100000 units/day ophthalmic administration Polymyxin B polymyxin B sulfate PDR
Max dose for children 20000.0 units/day 20000 units/day intrathecal administration Polymyxin B polymyxin B sulfate PDR
Max dose for children 25000.0 units/kg/day 25000 units/kg/day ophthalmic administration;total systemic; Polymyxin B polymyxin B sulfate PDR
Max dose for adolescents 25000.0 units/kg/day 25000 units/kg/day intravenous injection, IV Polymyxin B polymyxin B sulfate PDR
Max dose for adolescents 30000.0 units/kg/day 30000 units/kg/day IM,intramuscular injection Polymyxin B polymyxin B sulfate PDR
Max dose for adolescents 100000.0 units/day 100000 units/day ophthalmic administration Polymyxin B polymyxin B sulfate PDR
Max dose for adolescents 50000.0 units/day 50000 units/day intrathecal administration Polymyxin B polymyxin B sulfate PDR
Max dose for adolescents 25000.0 units/kg/day 25000 units/kg/day ophthalmic administration;total systemic; Polymyxin B polymyxin B sulfate PDR
Max dose for adults 25000.0 units/kg/day 25000 units/kg/day intravenous injection, IV Polymyxin B polymyxin B sulfate PDR
Max dose for adults 30000.0 units/kg/day 30000 units/kg/day IM,intramuscular injection Polymyxin B polymyxin B sulfate PDR
Max dose for adults 100000.0 units/day 100000 units/day ophthalmic administration Polymyxin B polymyxin B sulfate PDR
Max dose for adults 50000.0 units/day 50000 units/day intrathecal administration Polymyxin B polymyxin B sulfate PDR
Max dose for adults 25000.0 units/kg/day 25000 units/kg/day ophthalmic administration;total systemic; Polymyxin B polymyxin B sulfate PDR
Max dose for geriatric 25000.0 units/kg/day 25000 units/kg/day intravenous injection, IV Polymyxin B polymyxin B sulfate PDR
Max dose for geriatric 30000.0 units/kg/day 30000 units/kg/day IM,intramuscular injection Polymyxin B polymyxin B sulfate PDR
Max dose for geriatric 100000.0 units/day 100000 units/day ophthalmic administration Polymyxin B polymyxin B sulfate PDR
Max dose for geriatric 50000.0 units/day 50000 units/day intrathecal administration Polymyxin B polymyxin B sulfate PDR
Max dose for geriatric 25000.0 units/kg/day 25000 units/kg/day ophthalmic administration;total systemic; Polymyxin B polymyxin B sulfate PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1