Basic Information
| Drug ID | DDPD00779 |
|
| Drug Name | Nalidixic acid | |
| Molecular Weight | 232.2353 | |
| Molecular Formula | C12H12N2O3 | |
| CAS Number | 389-08-2 | |
| SMILES | CCN1C=C(C(O)=O)C(=O)C2=C1N=C(C)C=C2 | |
| External Links | ||
| DRUGBANK | DB00779 | |
| PubChem Compound | 4421 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 1.59 | - | 1.59 | - | BIOBYTE (1995) |
| Melting Point | 229.5 | ℃ | 229.5 | ℃ | PhysProp |
| Water Solubility | 100.0 | mg/L | 100 | mg/L | MERCK INDEX 1996) |
| pKa | 8.6 | - | 8.6 | - | OSOL,A & HOOVER,JE (1975) |
| Log S | -3.37 | - | -3.37 | - | ADME Research, USCD |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 96.0 | % | 96 | % | PO, oral; | DRUGBANK |
| Metabolic | 30.0 | % | 30 | % | Liver metabolism; Active metabolite; | DRUGBANK |
| Half-life | 1.8 | h | 1.1-2.5 | h | normal,healthy; adults; | DRUGBANK | Half-life | 21.0 | h | 21 | h | RD, renal impairment, Renal disease，including uremia; patients; | DRUGBANK |
| Toxicity LD50 | 1160.0 | mg/kg | 1160.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 572.0 | mg/kg | 572.0 | mg/kg | PO, oral; mouse; | DRUGBANK |
| Eliminate Route | 4.0 | % | ~4 | % | Faeces excretion; | DRUGBANK |
| Protein Binding | 93.0 | % | 93 | % | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1