Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00776 ...
Drug Name Oxcarbazepine
Molecular Weight 252.268
Molecular Formula C15H12N2O2
CAS Number 28721-07-5
SMILES NC(=O)N1C2=CC=CC=C2CC(=O)C2=C1C=CC=C2
External Links
DRUGBANK DB00776
T3DB T3D2887
PubChem Compound 34312
PDR 1806
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 1.5 - 1.5 - DRUGBANK
pKa 13.73 - 13.73 - Canadian label

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 100.0 % 100 % PO, oral; food; food → ; DRUGBANK
C Max 34.0 ng/ml 34.0 umol/L Oral single dose; DRUGBANK
C Max 8500.0 ng/ml 8.5±2.0 mcg/ml PO, oral; The Pharmacological Basis of Therapeutics
T Max 4.5 h 4.5 h Oral single dose; DRUGBANK
T Max 3.0 h 2-4 h PO, oral; The Pharmacological Basis of Therapeutics
Tss 60.0 h 2-3 day Oral multiple dose; DRUGBANK
Clearance 84.9 L/h ~84.9 L/h Plasma clearance; DRUGBANK
Clearance 2.0 L/h 2.0 L/h Plasma clearance; Renal metabolism; DRUGBANK
Clearance 4.0 L/h/kg 67.4 ml/min/kg apparent clearance; metabolism of ugt; The Pharmacological Basis of Therapeutics
Volume of Distribution 49.0 L 49.0 L Apparent volume of distribution; DRUGBANK
Volume of Distribution 23.6 L 23.6 L Apparent volume of distribution; DRUGBANK
Volume of Distribution 31.7 L 31.7 L Apparent volume of distribution; DRUGBANK
Half-life 2.0 h ~2 h elimination half-life; DRUGBANK
Half-life 9.0 h ~9 h elimination half-life; DRUGBANK
Half-life 2.0 h ~2 h normal,healthy; adults; Male, men; The Pharmacological Basis of Therapeutics
Half-life 11.5 h 8-15 h Active metabolite; RD, renal impairment, Renal disease，including uremia ↑ ;Age ↑ ; The Pharmacological Basis of Therapeutics
Toxicity LD50 1240.0 mg/kg 1240.0 mg/kg PO, oral; mammals; DRUGBANK
Toxicity TDLo 73.0 mg/kg 73.0 mg/kg PO, oral; Children; DRUGBANK
Eliminate Route 95.0 % >95 % Urinary excretion; PO, oral; DRUGBANK
Eliminate Route 4.0 % 4 % Faeces excretion; PO, oral; DRUGBANK
Eliminate Route 1.0 % <1 % Urinary excretion; PO, oral; Unchanged drug; DRUGBANK
Eliminate Route 1.0 % <1 % Urinary excretion; adults; Male, men; normal,healthy; Unchanged drug; The Pharmacological Basis of Therapeutics
Eliminate Route 27.0 % 27 % Urinary excretion; adults; Male, men; normal,healthy; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 45.0 % 45 % Active metabolite; adults; Male, men; normal,healthy; human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 60.0 mg/kg/day 60 mg/kg/day PO, oral Trileptal oxcarbazepine PDR
Max dose for adolescents 2400.0 mg/day 2400 mg/day PO, oral Trileptal oxcarbazepine PDR
Max dose for adults 2400.0 mg/day 2400 mg/day PO, oral Trileptal oxcarbazepine PDR
Max dose for geriatric 2400.0 mg/day 2400 mg/day PO, oral Trileptal oxcarbazepine PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1