Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00774 ...
Drug Name Hydroflumethiazide
Molecular Weight 331.292
Molecular Formula C8H8F3N3O4S2
CAS Number 135-09-1
SMILES NS(=O)(=O)C1=CC2=C(NCNS2(=O)=O)C=C1C(F)(F)F
External Links
DRUGBANK DB00774
PubChem Compound 3647

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 0.36 - 0.36 - HANSCH,C ET AL. (1995)
Melting Point 272.5 ℃ 272-273 ℃ U.S. Patent 3,254,076.
Water Solubility 300.0 mg/L 300 mg/L MERCK INDEX 1996)
pKa 8.9 - 8.9 - BUDAVARI,S ET AL. (1996)

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Clearance 0.58 L/h/kg 9.7 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 2.2 L/kg 2.2 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 2.0 h ~2 h distribution half-life; DRUGBANK
Half-life 17.0 h ~17 h elimination half-life; DRUGBANK
Half-life 5.2 h 5.2 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Protein Binding 74.0 % 74 % DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1