Basic Information
| Drug ID | DDPD00770 |
|
| Drug Name | Alprostadil | |
| Molecular Weight | 354.487 | |
| Molecular Formula | C20H34O5 | |
| CAS Number | 745-65-3 | |
| SMILES | CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O | |
| External Links | ||
| DRUGBANK | DB00770 | |
| PubChem Compound | 149351 | |
| PDR | 1013 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 3.2 | - | 3.2 | - | AVDEEF,A ET AL. (1995) |
| Melting Point | 115.5 | ℃ | 115-116 | ℃ | DRUGBANK |
| Water Solubility | 26.7 | mg/L | 26.7 | mg/L | DRUGBANK |
| pKa | 4.85 | - | 4.85 | - | AVDEEF,A ET AL. (1995) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Metabolic | 80.0 | % | 80 | % | lung metabolism; | DRUGBANK |
| Clearance | 2.7 | L/h/kg | 45.4 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 2.4 | L/kg | 2.4 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 0.13 | h | 5-10 | min | Single dose; normal,healthy; adults; Neonates; | DRUGBANK | Half-life | 1.9 | h | 1.9 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 186.0 | mg/kg | 186.0 | mg/kg | PO, oral; mouse; | DRUGBANK | Toxicity LD50 | 228.0 | mg/kg | 228.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK |
| Protein Binding | 81.0 | % | 81 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 0.576 | mg/kg/day | 0.4 | mcg/kg/minute | intravenous injection, IV | Prostin VR Pediatric | alprostadil | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1