Basic Information
| Drug ID | DDPD00768 |
|
| Drug Name | Olopatadine | |
| Molecular Weight | 337.4122 | |
| Molecular Formula | C21H23NO3 | |
| CAS Number | 113806-05-6 | |
| SMILES | CN(C)CC\C=C1\C2=CC=CC=C2COC2=C1C=C(CC(O)=O)C=C2 | |
| External Links | ||
| DRUGBANK | DB00768 | |
| T3DB | T3D2886 | |
| PubChem Compound | 5281071 | |
| PDR | 1710 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 9.7 | ng.h/ml | 9.7±4.4 | ng.h/ml | ophthalmic administration; normal,healthy; | DRUGBANK | AUC | 66.0 | ng.h/ml | 66±26.8 | ng.h/ml | inhalation, IH; normal,healthy; | DRUGBANK | AUC | 78.0 | ng.h/ml | 78.0±13.9 | ng.h/ml | inhalation, IH; allergic rhinitis; | DRUGBANK |
| Bioavailability | 57.0 | % | 57 | % | inhalation, IH; normal,healthy; | DRUGBANK |
| C Max | 1.6 | ng/ml | 1.6±0.9 | ng/ml | ophthalmic administration; normal,healthy; | DRUGBANK | C Max | 6.0 | ng/ml | 6.0±8.99 | ng/ml | inhalation, IH; normal,healthy; | DRUGBANK | C Max | 23.3 | ng/ml | 23.3±6.2 | ng/ml | inhalation, IH; allergic rhinitis; | DRUGBANK |
| T Max | 2.0 | h | 2 | h | ophthalmic administration; normal,healthy; | DRUGBANK |
| Tss | 0.75 | h | 0.5-1 | h | inhalation, IH; normal,healthy; | DRUGBANK | Tss | 1.1 | h | 0.25-2 | h | inhalation, IH; allergic rhinitis; | DRUGBANK |
| Clearance | 23.5 | L/h | 23.45 | L/h | Average clearance; PO, oral; normal,healthy; | DRUGBANK |
| Volume of Distribution | 133.8 | L | 133.83 | L | normal,healthy; | DRUGBANK |
| Half-life | 3.4 | h | 3.4±1.2 | h | elimination half-life; ophthalmic administration; | DRUGBANK | Half-life | 10.0 | h | 8-12 | h | elimination half-life; PO, oral; | DRUGBANK |
| Toxicity LD50 | 1150.0 | mg/kg | >1150 | mg/kg | PO, oral; mouse; | DRUGBANK | Toxicity LD50 | 3870.0 | mg/kg | >3870 | mg/kg | Rattus, Rat; | DRUGBANK |
| Toxicity TDLo | 20.0 | mg/kg | 20.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity TDLo | 0.10 | mg/kg | 0.1 | mg/kg | PO, oral; mouse; | DRUGBANK |
| Eliminate Route | 70.0 | % | ~70 | % | Urinary excretion; PO, oral; | DRUGBANK | Eliminate Route | 17.0 | % | ~17 | % | Faeces excretion; | DRUGBANK |
| Protein Binding | 55.0 | % | ~55 | % | human, homo sapiens; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 2.0 | drop/day | 2 | drop/day | ophthalmic administration | Patanol | olopatadine hydrochloride | PDR |
| Max dose for children | 1.0 | drop/day | 1 | drop/day | ophthalmic administration | Patanol | olopatadine hydrochloride | PDR |
| Max dose for children | 4.0 | sprays/day | 4 | sprays/day | nasal spray | Patanol | olopatadine hydrochloride | PDR |
| Max dose for children | 2.0 | drop/day | 2 | drop/day | ophthalmic administration | Patanol | olopatadine hydrochloride | PDR |
| Max dose for children | 1.0 | drop/day | 1 | drop/day | ophthalmic administration | Patanol | olopatadine hydrochloride | PDR |
| Max dose for children | 2.0 | sprays/day | 2 | sprays/day | nasal spray | Patanol | olopatadine hydrochloride | PDR |
| Max dose for children | 2.0 | drop/day | 2 | drop/day | ophthalmic administration | Patanol | olopatadine hydrochloride | PDR |
| Max dose for children | 1.0 | drop/day | 1 | drop/day | ophthalmic administration | Patanol | olopatadine hydrochloride | PDR |
| Max dose for children | 2.0 | sprays/day | 2 | sprays/day | nasal spray | Patanol | olopatadine hydrochloride | PDR |
| Max dose for adolescents | 2.0 | drop/day | 2 | drop/day | ophthalmic administration | Patanol | olopatadine hydrochloride | PDR |
| Max dose for adolescents | 1.0 | drop/day | 1 | drop/day | ophthalmic administration | Patanol | olopatadine hydrochloride | PDR |
| Max dose for adolescents | 4.0 | sprays/day | 4 | sprays/day | nasal spray | Patanol | olopatadine hydrochloride | PDR |
| Max dose for adults | 2.0 | drop/day | 2 | drop/day | ophthalmic administration | Patanol | olopatadine hydrochloride | PDR |
| Max dose for adults | 1.0 | drop/day | 1 | drop/day | ophthalmic administration | Patanol | olopatadine hydrochloride | PDR |
| Max dose for adults | 4.0 | sprays/day | 4 | sprays/day | nasal spray | Patanol | olopatadine hydrochloride | PDR |
| Max dose for geriatric | 2.0 | drop/day | 2 | drop/day | ophthalmic administration | Patanol | olopatadine hydrochloride | PDR |
| Max dose for geriatric | 1.0 | drop/day | 1 | drop/day | ophthalmic administration | Patanol | olopatadine hydrochloride | PDR |
| Max dose for geriatric | 4.0 | sprays/day | 4 | sprays/day | nasal spray | Patanol | olopatadine hydrochloride | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1