DETAILS

Property Name	Property Value	Unit	Raw Value	Raw Unit	Reference
Log P	-2.3	-	-2.3	-	https://www.speronline.com/japer/Articlefile/202.pdf
Boiling Point	545.8	℃	545.8	℃	http://clav-acid.weebly.com/physical-characteristics.html
Melting Point	117.75	℃	117.5-118	℃	http://clav-acid.weebly.com/physical-characteristics.html
pKa	2.7	-	2.7	-	http://wildpro.twycrosszoo.org/S/00Chem/ChComplex/Clavulanic_acid.htm
Log S	0.23	-	0.23	-	http://www.hmdb.ca/metabolites/HMDB0014904

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Reference
Absorption	73.0	%	73	%	PO, oral;	DRUGBANK
Bioavailability	64.0	%	64	%	PO, oral;	DRUGBANK
C Max	2098.0	ng/ml	2.098±0.441	mcg/ml	PO, oral;	DRUGBANK
T Max	1.0	h	1.042±0.8	h	PO, oral;	DRUGBANK
T Max	1.3	h	0.67-2	h	PO, oral; different study;	DRUGBANK
Metabolic	15.6	%	15.6	%		DRUGBANK
Metabolic	8.8	%	8.8	%		DRUGBANK
Clearance	12.6	L/h	0.21	L/min	normal,healthy;	DRUGBANK
Clearance	0.17	L/h/kg	12.2	L/h/70kg	Average clearance;	DRUGBANK
Clearance	0.19	L/h/kg	3.1	ml/min/kg	intravenous injection, IV; human, homo sapiens;	Human Intravenous Pharmacokinetic Dataset
Volume of Distribution	12.0	L	12.0	L	normal,healthy;	DRUGBANK
Volume of Distribution	0.22	L/kg	0.22	L/kg	intravenous injection, IV; human, homo sapiens;	Human Intravenous Pharmacokinetic Dataset
Half-life	1.1	h	45-90	min		DRUGBANK
Half-life	0.80	h	0.8	h	normal,healthy;	DRUGBANK
Half-life	0.90	h	0.9	h	intravenous injection, IV; human, homo sapiens;	Human Intravenous Pharmacokinetic Dataset
Toxicity LD50	2000.0	mg/kg	>2000	mg/kg	PO, oral; adults; rodents;	DRUGBANK
Eliminate Route	8.0	%	8	%	Faeces excretion;	DRUGBANK
Eliminate Route	52.5	%	~40-65	%	Urinary excretion; Unchanged drug;	DRUGBANK
Protein Binding	25.0	%	~25	%	plasma proteins;	DRUGBANK

Not Available

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1