Basic Information
| Drug ID | DDPD00765 |
|
| Drug Name | Metyrosine | |
| Molecular Weight | 195.2151 | |
| Molecular Formula | C10H13NO3 | |
| CAS Number | 672-87-7 | |
| SMILES | C[C@](N)(CC1=CC=C(O)C=C1)C(O)=O | |
| External Links | ||
| DRUGBANK | DB00765 | |
| PubChem Compound | 441350 | |
| PDR | 2028 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -1.7 | - | -1.7 | - | DRUGBANK |
| Melting Point | 312.5 | ℃ | 312.5 | ℃ | PhysProp |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Metabolic | 1.0 | % | <1 | % | DRUGBANK | |
| Half-life | 3.6 | h | 3.4-3.7 | h | DRUGBANK | |
| Toxicity LD50 | 442.0 | mg/kg | 442.0 | mg/kg | mouse; | DRUGBANK | Toxicity LD50 | 752.0 | mg/kg | 752.0 | mg/kg | Rattus, Rat; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adolescents | 4000.0 | mg/day | 4 | g/day | PO, oral | Demser | metyrosine | PDR |
| Max dose for adults | 4000.0 | mg/day | 4 | g/day | PO, oral | Demser | metyrosine | PDR |
| Max dose for elderly | 4000.0 | mg/day | 4 | g/day | PO, oral | Demser | metyrosine | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1