Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00763 ...
Drug Name Methimazole
Molecular Weight 114.169
Molecular Formula C4H6N2S
CAS Number 60-56-0
SMILES CN1C=CNC1=S
External Links
DRUGBANK DB00763
PubChem Compound 1349907
PDR 1493
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Melting Point 144.5 ℃ 143-146 ℃ DPD Label (Canada)

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 93.0 % 93 % PO, oral; DRUGBANK
T Max 2.1 h 0.25-4 h PO, oral; DRUGBANK
Clearance 5.7 L/h 5.7 L/h intravenous injection, IV; Single dose; DRUGBANK
Clearance 3.5 L/h 3.49 L/h moderate hepatic impairment; patients; hepatopathy，LD ↓ ; DRUGBANK
Clearance 0.84 L/h 0.84 L/h severe hepatic impairment; patients; hepatopathy，LD ↓ ; DRUGBANK
Clearance 0.22 L/h/kg 3.7 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 20.0 L ~20 L Apparent volume of distribution; DRUGBANK
Volume of Distribution 0.86 L/kg 0.86 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 0.17 h 0.17 h distribution half-life; RD, renal impairment, Renal disease，including uremia → ;hyperthyroid, HTh → ; DRUGBANK
Half-life 5.3 h 5.3 h elimination half-life; DRUGBANK
Half-life 16.4 h ~16.41 h DRUGBANK
Half-life 7.1 h 7.1 h mild hepatic impairment; DRUGBANK
Half-life 22.1 h 22.1 h severe hepatic impairment; DRUGBANK
Half-life 2.4 h 2.4 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 2250.0 mg/kg 2250.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Eliminate Route 3.0 % ~3 % Faeces excretion; DRUGBANK
Eliminate Route 9.5 % 7-12 % Urinary excretion; Unchanged drug; DRUGBANK
Protein Binding 0 % ~0 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for infants 30.0 mg/day 30 mg/day PO, oral Tapazole methimazole PDR
Max dose for infants 1.0 mg/kg/day 1 mg/kg/day PO, oral Tapazole methimazole PDR
Max dose for children 30.0 mg/day 30 mg/day PO, oral Tapazole methimazole PDR
Max dose for children 1.0 mg/kg/day 1 mg/kg/day PO, oral Tapazole methimazole PDR
Max dose for adolescents 40.0 mg/day 40 mg/day PO, oral Tapazole methimazole PDR
Max dose for adolescents 60.0 mg/day 60 mg/day PO, oral Tapazole methimazole PDR
Max dose for geriatric 40.0 mg/day 40 mg/day PO, oral Tapazole methimazole PDR
Max dose for geriatric 60.0 mg/day 60 mg/day PO, oral Tapazole methimazole PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1