Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00760 ...
Drug Name Meropenem
Molecular Weight 383.463
Molecular Formula C17H25N3O5S
CAS Number 96036-03-2
SMILES [H][C@]1([C@@H](C)O)C(=O)N2C(C(O)=O)=C(S[C@@H]3CN[C@@H](C3)C(=O)N(C)C)[C@H](C)[C@]12[H]
External Links
DRUGBANK DB00760
PubChem Compound 441130
PDR 2055
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P -0.6 - -0.6 - DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Clearance 0.23 L/h/kg 3.9 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.30 L/kg 0.3 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 1.0 h ~1 h Children; Adolescents; adults; DRUGBANK
Half-life 1.5 h ~1.5 h Infants; DRUGBANK
Half-life 1.0 h 1 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 70.0 % ~70 % Urinary excretion; intravenous injection, IV; Unchanged drug; DRUGBANK
Protein Binding 2.0 % ~2 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Frequency Brand Name Component Reference
Max dose for neonates 90.0 mg/kg/day 30 mg/kg/dose intravenous injection, IV q8h Merrem meropenem PDR
Max dose for neonates 120.0 mg/kg/day 40 mg/kg/dose intravenous injection, IV q8h Merrem meropenem PDR
Max dose for neonates 60.0 mg/kg/day 20 mg/kg/dose intravenous injection, IV q8h Merrem meropenem PDR
Max dose for neonates 120.0 mg/kg/day 40 mg/kg/dose intravenous injection, IV q8h Merrem meropenem PDR
Max dose for neonates 60.0 mg/kg/day 20 mg/kg/dose intravenous injection, IV q8h Merrem meropenem PDR
Max dose for neonates 120.0 mg/kg/day 40 mg/kg/dose intravenous injection, IV q8h Merrem meropenem PDR
Max dose for neonates 40.0 mg/kg/day 20 mg/kg/dose intravenous injection, IV q12h Merrem meropenem PDR
Max dose for neonates 120.0 mg/kg/day 40 mg/kg/dose intravenous injection, IV q8h Merrem meropenem PDR
Max dose for infants 120.0 mg/kg/day 40 mg/kg/dose intravenous injection, IV q8h Merrem meropenem PDR
Max dose for infants 90.0 mg/kg/day 30 mg/kg/dose intravenous injection, IV q8h Merrem meropenem PDR
Max dose for infants 120.0 mg/kg/day 40 mg/kg/dose intravenous injection, IV q8h Merrem meropenem PDR
Max dose for children 120.0 mg/kg/day 40 mg/kg/dose intravenous injection, IV q8h Merrem meropenem PDR
Max dose for children 2000.0 mg 2 g intravenous injection, IV q8h Merrem meropenem PDR
Max dose for adolescents 40.0 mg/kg/dose 40 mg/kg/dose intravenous injection, IV q8h Merrem meropenem PDR
Max dose for adolescents 6000.0 mg 2 g intravenous injection, IV q8h Merrem meropenem PDR
Max dose for adults 1000.0 mg 1 g intravenous injection, IV q8h Merrem meropenem PDR
Max dose for adults 2000.0 mg 2 g intravenous injection, IV q8h Merrem meropenem PDR
Max dose for geriatric 1000.0 mg 1 g intravenous injection, IV q8h Merrem meropenem PDR
Max dose for geriatric 2000.0 mg 2 g intravenous injection, IV q8h Merrem meropenem PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1