Basic Information
| Drug ID | DDPD00758 |
|
| Drug Name | Clopidogrel | |
| Molecular Weight | 321.822 | |
| Molecular Formula | C16H16ClNO2S | |
| CAS Number | 113665-84-2 | |
| SMILES | [H][C@@](N1CCC2=C(C1)C=CS2)(C(=O)OC)C1=CC=CC=C1Cl | |
| External Links | ||
| DRUGBANK | DB00758 | |
| PubChem Compound | 60606 | |
| PDR | 525 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Melting Point | 158.0 | ℃ | 158 | ℃ | http://www.chemspider.com/Chemical-Structure.54632.html?rid=9b9b483b-9db2-454c-a1be-2494307b6b23&page_num=0 |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 50.0 | % | 50 | % | PO, oral; | DRUGBANK |
| AUC | 45.1 | ng.h/ml | 45.1±16.2 | ng.h/ml | PO, oral; poor metabolizers, PM; | DRUGBANK | AUC | 104.3 | ng.h/ml | 104.3±57.3 | ng.h/ml | PO, oral; high-fat meal; | DRUGBANK |
| C Max | 2.0 | ng/ml | 2.01±2.0 | ng/ml | PO, oral; | DRUGBANK | C Max | 31.3 | ng/ml | 31.3±13 | ng/ml | PO, oral; poor metabolizers, PM; | DRUGBANK | C Max | 60.8 | ng/ml | 60.8±34.3 | ng/ml | PO, oral; high-fat meal; | DRUGBANK |
| T Max | 0.75 | h | 0.5-1 | h | PO, oral; Active metabolite; | DRUGBANK | T Max | 1.4 | h | 1.40±1.07 | h | PO, oral; | DRUGBANK |
| Metabolic | 85.0 | % | 80-90 | % | Liver metabolism; PO, oral; Inactive metabolite; | DRUGBANK |
| Clearance | 18960.0 | L/h | 18960±15890 | L/h | PO, oral; | DRUGBANK | Clearance | 16980.0 | L/h | 16980±10410 | L/h | PO, oral; | DRUGBANK | Clearance | 1.4 | L/h/kg | 23.65 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 39240.0 | L | 39240±33520 | L | Apparent volume of distribution; | DRUGBANK | Volume of Distribution | 2.0 | L/kg | 2.01 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 6.0 | h | ~6 | h | PO, oral; | DRUGBANK | Half-life | 0.50 | h | ~30 | min | Active metabolite; | DRUGBANK | Half-life | 5.1 | h | 5.06 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity Lethal Dose | 1750.0 | mg/kg | 1500-2000 | mg/kg | Single dose; mouse; Rattus, Rat; | DRUGBANK | Toxicity Lethal Dose | 3000.0 | mg/kg | 3000.0 | mg/kg | Single dose; non-human primate; | DRUGBANK |
| Eliminate Route | 50.0 | % | 50 | % | Urinary excretion; PO, oral; | DRUGBANK | Eliminate Route | 46.0 | % | 46 | % | Faeces excretion; PO, oral; | DRUGBANK |
| Protein Binding | 98.0 | % | 98 | % | plasma proteins; | DRUGBANK | Protein Binding | 78.3 | % | 71-85.5 | % | cow; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 0.2 | mg/kg/day | 0.2 | mg/kg/day | PO, oral | Plavix | clopidogrel bisulfate | PDR |
| Max dose for infants | 0.2 | mg/kg/day | 0.2 | mg/kg/day | PO, oral | Plavix | clopidogrel bisulfate | PDR |
| Max dose for children | 6.0 | mg/kg/day | 6 | mg/kg/day | PO, oral | Plavix | clopidogrel bisulfate | PDR |
| Max dose for children | 75.0 | mg/day | 75 | mg/day | PO, oral | Plavix | clopidogrel bisulfate | PDR |
| Max dose for children | 0.2 | mg/kg/day | 0.2 | mg/kg/day | PO, oral | Plavix | clopidogrel bisulfate | PDR |
| Max dose for adolescents | 6.0 | mg/kg/day | 6 | mg/kg/day | PO, oral | Plavix | clopidogrel bisulfate | PDR |
| Max dose for adolescents | 75.0 | mg/day | 75 | mg/day | PO, oral | Plavix | clopidogrel bisulfate | PDR |
| Max dose for adults | 75.0 | mg/day | 75 | mg/day | PO, oral | Plavix | clopidogrel bisulfate | PDR |
| Max dose for adults | 600.0 | mg | 600 | mg | PO, oral | Plavix | clopidogrel bisulfate | PDR |
| Max dose for geriatric | 75.0 | mg/day | 75 | mg/day | PO, oral | Plavix | clopidogrel bisulfate | PDR |
| Max dose for geriatric | 600.0 | mg | 600 | mg | PO, oral | Plavix | clopidogrel bisulfate | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1