Basic Information
| Drug ID | DDPD00755 |
|
| Drug Name | Tretinoin | |
| Molecular Weight | 300.442 | |
| Molecular Formula | C20H28O2 | |
| CAS Number | 302-79-4 | |
| SMILES | C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O | |
| External Links | ||
| DRUGBANK | DB00755 | |
| T3DB | T3D2884 | |
| PubChem Compound | 5538 | |
| PDR | 1786 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 6.3 | - | 6.3 | - | HANSCH,C ET AL. (1995) |
| Melting Point | 181.0 | ℃ | 181 | ℃ | PhysProp |
| Water Solubility | 1000.0 | mg/L | <0.1 | g/100ml | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 16.0 | % | 1-31 | % | skin/dermal; | DRUGBANK |
| Half-life | 1.3 | h | 0.5-2 | h | DRUGBANK | |
| Protein Binding | 95.0 | % | >95 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 45.0 | mg/m2/day | 45 | mg/m2/day | PO, oral | Avita Cream | tretinoin | PDR |
| Max dose for adolescents | 45.0 | mg/m2/day | 45 | mg/m2/day | PO, oral | Avita Cream | tretinoin | PDR |
| Max dose for adults | 45.0 | mg/m2/day | 45 | mg/m2/day | PO, oral | Avita Cream | tretinoin | PDR |
| Max dose for geriatric | 45.0 | mg/m2/day | 45 | mg/m2/day | PO, oral | Avita Cream | tretinoin | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1