Basic Information

Drug ID DDPD00749 ...
Drug Name Etodolac
Molecular Weight 287.3535
Molecular Formula C17H21NO3
CAS Number 41340-25-4
SMILES CCC1=C2NC3=C(CCOC3(CC)CC(O)=O)C2=CC=C1
External Links
DRUGBANK DB00749
PubChem Compound 3308
PDR 712
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.5 - 2.5 - DRUGBANK
Melting Point 146.5 146.5 PhysProp
Water Solubility 16.0 mg/L 16 mg/L DRUGBANK
pKa 4.65 - 4.65 - DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 80.0 % >80 % Tablet, PO, oral; Capsule, PO, Oral; DRUGBANK
Metabolic 1.0 % 1 % Urinary excretion; Unchanged drug; DRUGBANK
Metabolic 13.0 % 13 % Urinary excretion; DRUGBANK
Metabolic 5.0 % 5 % Urinary excretion; DRUGBANK
Metabolic 20.0 % 20 % Urinary excretion; DRUGBANK
Metabolic 16.0 % 16 % Faeces excretion; DRUGBANK
Clearance 2.9 L/h/kg 49.1 ml/min/kg Total clearance; PO, oral; normal,healthy; adults; DRUGBANK
Clearance 3.0 L/h/kg 49.4 ml/min/kg normal,healthy; Male, men; DRUGBANK
Clearance 2.1 L/h/kg 35.7 ml/min/kg normal,healthy;  Female, women; DRUGBANK
Clearance 2.7 L/h/kg 45.7 ml/min/kg Elderly; DRUGBANK
Clearance 3.5 L/h/kg 58.3 ml/min/kg RD, renal impairment, Renal disease,including uremia; DRUGBANK
Clearance 2.5 L/h/kg 42.0 ml/min/kg hepatopathy,LD; DRUGBANK
Volume of Distribution 0.39 L/kg 390.0 mL/kg DRUGBANK
Half-life 7.3 h 7.3±4 h terminal half-life; DRUGBANK
Half-life 0.71 h 0.71±0.5 h distribution half-life; DRUGBANK
Eliminate Route 16.0 % 16 % Faeces excretion; DRUGBANK
Eliminate Route 72.0 % 72 % Urinary excretion; DRUGBANK
Eliminate Route 1.0 % ~1 % Urinary excretion; Unchanged drug; DRUGBANK
Protein Binding 99.0 % >99 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 400.0 mg/day 400 mg/day Tablet,PO,oral Etodolac Capsules and Tablets etodolac PDR
Max dose for children 600.0 mg/day 600 mg/day Tablet,PO,oral Etodolac Capsules and Tablets etodolac PDR
Max dose for children 800.0 mg/day 800 mg/day Tablet,PO,oral Etodolac Capsules and Tablets etodolac PDR
Max dose for children 1000.0 mg/day 1000 mg/day Tablet,PO,oral Etodolac Capsules and Tablets etodolac PDR
Max dose for adolescents 400.0 mg/day 400 mg/day Tablet,PO,oral Etodolac Capsules and Tablets etodolac PDR
Max dose for adolescents 600.0 mg/day 600 mg/day Tablet,PO,oral Etodolac Capsules and Tablets etodolac PDR
Max dose for adolescents 800.0 mg/day 800 mg/day Tablet,PO,oral Etodolac Capsules and Tablets etodolac PDR
Max dose for adolescents 1000.0 mg/day 1000 mg/day Tablet,PO,oral Etodolac Capsules and Tablets etodolac PDR
Max dose for adults 1200.0 mg/day 1200 mg/day PO, oral Etodolac Capsules and Tablets etodolac PDR
Max dose for elderly 1200.0 mg/day 1200 mg/day PO, oral Etodolac Capsules and Tablets etodolac PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1