Basic Information
| Drug ID | DDPD00744 |
|
| Drug Name | Zileuton | |
| Molecular Weight | 236.29 | |
| Molecular Formula | C11H12N2O2S | |
| CAS Number | 111406-87-2 | |
| SMILES | CC(N(O)C(N)=O)C1=CC2=CC=CC=C2S1 | |
| External Links | ||
| DRUGBANK | DB00744 | |
| PubChem Compound | 60490 | |
| PDR | 1260 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 0.9 | - | 0.9 | - | DRUGBANK |
| Melting Point | 144.7 | ℃ | 144.2-145. | ℃ | DRUGBANK |
| Water Solubility | 500.0 | mg/L | 0.5 | mg/ml | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 100.0 | % | ~100 | % | DRUGBANK | |
| Clearance | 0.42 | L/h/kg | 7.0 | ml/min/kg | Total clearance; PO, oral; | DRUGBANK |
| Volume of Distribution | 1.2 | L/kg | 1.2 | L/kg | DRUGBANK | |
| Half-life | 2.5 | h | 2.5 | h | DRUGBANK | |
| Toxicity LDLo | 2250.0 | mg/kg | 500-4000 | mg/kg | PO, oral; mouse; | DRUGBANK | Toxicity LDLo | 650.0 | mg/kg | 300-1000 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK |
| Eliminate Route | 0.50 | % | <0.5 | % | Urinary excretion; Unchanged drug; | DRUGBANK |
| Protein Binding | 93.0 | % | 93 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 2400.0 | mg/day | 2400 | mg/day | PO, oral | Zyflo | zileuton | PDR |
| Max dose for adolescents | 2400.0 | mg/day | 2400 | mg/day | PO, oral | Zyflo | zileuton | PDR |
| Max dose for adults | 2400.0 | mg/day | 2400 | mg/day | PO, oral | Zyflo | zileuton | PDR |
| Max dose for geriatric | 2400.0 | mg/day | 2400 | mg/day | PO, oral | Zyflo | zileuton | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1