Basic Information
| Drug ID | DDPD00742 |
|
| Drug Name | Mannitol | |
| Molecular Weight | 182.1718 | |
| Molecular Formula | C6H14O6 | |
| CAS Number | 69-65-8 | |
| SMILES | OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO | |
| External Links | ||
| DRUGBANK | DB00742 | |
| PubChem Compound | 6251 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Caco-2 Permeability | -6.21 | - | -6.21 | - | ADME Research, USCD |
| Log P | -3.1 | - | -3.1 | - | HANSCH,C ET AL. (1995) |
| Boiling Point | 292.5 | ℃ | 290-295 | ℃ | PhysProp |
| Melting Point | 168.0 | ℃ | 168 | ℃ | PhysProp |
| Water Solubility | 216000.0 | mg/L | 216000 | mg/L | YALKOWSKY,SH & DANNENFELSER,RM 1992) |
| pKa | 13.5 | - | 13.5 | - | BUDAVARI,S ET AL. (1996) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 7.0 | % | 7 | % | Rectal Administration; RD, renal impairment, Renal disease，including uremia; | DRUGBANK |
| Clearance | 0.0720 | L/h/kg | 1.2 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.24 | L/kg | 0.24 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 1.7 | h | 100 | min | DRUGBANK | Half-life | 4.7 | h | 4.7 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 1700.0 | mg/kg | 1700.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1