Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00741 ...
Drug Name Hydrocortisone
Molecular Weight 362.4599
Molecular Formula C21H30O5
CAS Number 50-23-7
SMILES [H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
External Links
DRUGBANK DB00741
PubChem Compound 5754
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Caco-2 Permeability -4.66 - -4.66 - ADME Research, USCD
Log P 1.61 - 1.61 - HANSCH,C ET AL. (1995)
Melting Point 220.0 ℃ 220 ℃ PhysProp
Water Solubility 320.0 mg/L 320 mg/L YALKOWSKY,SH & DANNENFELSER,RM 1992)
Log S -2.97 - -2.97 - ADME Research, USCD

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 32.8 ng.h/ml 90.63 nmol.h/L PO, oral; DRUGBANK
AUC 72.2 ng.h/ml 199.1 nmol.h/L PO, oral; DRUGBANK
AUC 1163.0 ng.h/ml 1163±277 ng.h/ml intravenous injection, IV; DRUGBANK
Bioavailability 11.5 % 4-19 % skin/dermal; DRUGBANK
Bioavailability 50.2 % 50.2 % Rectal Administration; immediate release formulation; DRUGBANK
Bioavailability 81.0 % 81 % Rectal Administration; extended release formulation; DRUGBANK
C Max 11.8 ng/ml 32.69 nmol/L PO, oral; DRUGBANK
C Max 25.7 ng/ml 70.81 nmol/L PO, oral; DRUGBANK
T Max 24.0 h 24 h skin/dermal; DRUGBANK
Clearance 12.9 L/h 12.85 L/h Average clearance; PO, oral; DRUGBANK
Clearance 18.2 L/h 18.2±4.2 L/h intravenous injection, IV; DRUGBANK
Clearance 0.34 L/h/kg 5.7 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 39.8 L 39.82 L Total volume of distribution; DRUGBANK
Volume of Distribution 474.4 L 474.38 L Total volume of distribution; DRUGBANK
Volume of Distribution 0.38 L/kg 0.38 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 2.2 h 2.15 h PO, oral; DRUGBANK
Half-life 1.4 h 1.39 h DRUGBANK
Half-life 1.9 h 1.9±0.4 h terminal half-life; intravenous injection, IV; DRUGBANK
Half-life 1.6 h 1.6 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Protein Binding 90.1 % 90.1 % plasma proteins; DRUGBANK
Protein Binding 56.2 % 56.2 % DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1