Basic Information

Drug ID DDPD00740 ...
Drug Name Riluzole
Molecular Weight 234.198
Molecular Formula C8H5F3N2OS
CAS Number 1744-22-5
SMILES NC1=NC2=C(S1)C=C(OC(F)(F)F)C=C2
External Links
DRUGBANK DB00740
T3DB T3D2875
PubChem Compound 5070
PDR 526
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.3 - 2.3 - DRUGBANK
Melting Point 119.0 119 DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 90.0 % ~90 % PO, oral; DRUGBANK
Bioavailability 60.0 % 60 % PO, oral; DRUGBANK
Bioavailability 64.0 % 64(30-100) % PO, oral; The Pharmacological Basis of Therapeutics
C Max 173.0 ng/ml 173±72 ng/ml PO, oral; The Pharmacological Basis of Therapeutics
T Max 0.80 h 0.8±0.5 h PO, oral; The Pharmacological Basis of Therapeutics
Clearance 0.33 L/h/kg 5.5±0.9 ml/min/kg hydrolysis; hepatopathy,LD ↓ ; The Pharmacological Basis of Therapeutics
Clearance 0.68 L/h/kg 11.3 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 3.4 L/kg 3.4±0.6 L/kg hydrolysis; The Pharmacological Basis of Therapeutics
Volume of Distribution 3.5 L/kg 3.5 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 12.0 h 12 h elimination half-life; skin/dermal; DRUGBANK
Half-life 14.0 h 14±6 h The Pharmacological Basis of Therapeutics
Toxicity LD50 85.0 mg/kg 85.0 mg/kg PO, oral; mouse; T3DB
Toxicity LD50 34.5 mg/kg 34.5 mg/kg intravenous injection, IV; mouse; T3DB
Toxicity LD50 45.0 mg/kg 45.0 mg/kg PO, oral; Rattus, Rat; T3DB
Toxicity LD50 21.0 mg/kg 21.0 mg/kg intravenous injection, IV; mouse; T3DB
Eliminate Route 1.0 % <1 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 96.0 % 96 % plasma proteins; DRUGBANK
Protein Binding 98.0 % 98 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 100.0 mg/day 100 mg/day PO, oral Rilutek riluzole PDR
Max dose for adults 200.0 mg/day 200 mg/day PO, oral Rilutek riluzole PDR
Max dose for geriatric 100.0 mg/day 100 mg/day PO, oral Rilutek riluzole PDR
Max dose for geriatric 200.0 mg/day 200 mg/day PO, oral Rilutek riluzole PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1