Property Name |
Property Value |
Unit |
Raw Value |
Raw Unit |
Annotation |
Factor |
Reference |
Absorption |
90.0 |
% |
~90 |
% |
PO, oral; |
|
DRUGBANK |
Bioavailability |
60.0 |
% |
60 |
% |
PO, oral; |
|
DRUGBANK |
Bioavailability |
64.0 |
% |
64(30-100) |
% |
PO, oral; |
|
The Pharmacological Basis of Therapeutics |
C Max |
173.0 |
ng/ml |
173±72 |
ng/ml |
PO, oral; |
|
The Pharmacological Basis of Therapeutics |
T Max |
0.80 |
h |
0.8±0.5 |
h |
PO, oral; |
|
The Pharmacological Basis of Therapeutics |
Clearance |
0.33 |
L/h/kg |
5.5±0.9 |
ml/min/kg |
hydrolysis; |
hepatopathy,LD ↓ ; |
The Pharmacological Basis of Therapeutics |
Clearance |
0.68 |
L/h/kg |
11.3 |
ml/min/kg |
intravenous injection, IV; human, homo sapiens; |
|
Human Intravenous Pharmacokinetic Dataset |
Volume of Distribution |
3.4 |
L/kg |
3.4±0.6 |
L/kg |
hydrolysis; |
|
The Pharmacological Basis of Therapeutics |
Volume of Distribution |
3.5 |
L/kg |
3.5 |
L/kg |
intravenous injection, IV; human, homo sapiens; |
|
Human Intravenous Pharmacokinetic Dataset |
Half-life |
12.0 |
h |
12 |
h |
elimination half-life; skin/dermal; |
|
DRUGBANK |
Half-life |
14.0 |
h |
14±6 |
h |
|
|
The Pharmacological Basis of Therapeutics |
Toxicity LD50 |
85.0 |
mg/kg |
85.0 |
mg/kg |
PO, oral; mouse; |
|
T3DB |
Toxicity LD50 |
34.5 |
mg/kg |
34.5 |
mg/kg |
intravenous injection, IV; mouse; |
|
T3DB |
Toxicity LD50 |
45.0 |
mg/kg |
45.0 |
mg/kg |
PO, oral; Rattus, Rat; |
|
T3DB |
Toxicity LD50 |
21.0 |
mg/kg |
21.0 |
mg/kg |
intravenous injection, IV; mouse; |
|
T3DB |
Eliminate Route |
1.0 |
% |
<1 |
% |
Urinary excretion; Unchanged drug; |
|
The Pharmacological Basis of Therapeutics |
Protein Binding |
96.0 |
% |
96 |
% |
plasma proteins; |
|
DRUGBANK |
Protein Binding |
98.0 |
% |
98 |
% |
|
|
The Pharmacological Basis of Therapeutics |