Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00738 ...
Drug Name Pentamidine
Molecular Weight 340.4195
Molecular Formula C19H24N4O2
CAS Number 100-33-4
SMILES NC(=N)C1=CC=C(OCCCCCOC2=CC=C(C=C2)C(N)=N)C=C1
External Links
DRUGBANK DB00738
T3DB T3D3526
PubChem Compound 4735
PDR 1408
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 4.0 - 4.0 - DRUGBANK
Melting Point 186.0 ℃ 186 ℃ DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Clearance 4.4 L/h/kg 74 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 53.0 L/kg 53 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 11.2 h 9.1-13.2 h DRUGBANK
Half-life 25.0 h 25 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Protein Binding 69.0 % 69 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for infants 4.0 mg/kg/day 4 mg/kg/day intravenous injection, IV;IM,intramuscular injection; NebuPent pentamidine isethionate PDR
Max dose for children 4.0 mg/kg/day 4 mg/kg/day intravenous injection, IV;IM,intramuscular injection; NebuPent pentamidine isethionate PDR
Max dose for children 300.0 mg/dose 300 mg/dose intravenous injection, IV;IM,intramuscular injection; NebuPent pentamidine isethionate PDR
Max dose for children 4.0 mg/kg/day 4 mg/kg/day intravenous injection, IV;IM,intramuscular injection; NebuPent pentamidine isethionate PDR
Max dose for children 300.0 mg/dose 300 mg/dose intravenous injection, IV;IM,intramuscular injection; NebuPent pentamidine isethionate PDR
Max dose for adolescents 4.0 mg/kg/day 4 mg/kg/day intravenous injection, IV;IM,intramuscular injection; NebuPent pentamidine isethionate PDR
Max dose for adolescents 300.0 mg/dose 300 mg/dose intravenous injection, IV;IM,intramuscular injection; NebuPent pentamidine isethionate PDR
Max dose for adolescents 4.0 mg/kg/day 4 mg/kg/day intravenous injection, IV;IM,intramuscular injection; NebuPent pentamidine isethionate PDR
Max dose for adolescents 300.0 mg/dose 300 mg/dose intravenous injection, IV;IM,intramuscular injection; NebuPent pentamidine isethionate PDR
Max dose for adults 4.0 mg/kg/day 4 mg/kg/day intravenous injection, IV;IM,intramuscular injection; NebuPent pentamidine isethionate PDR
Max dose for adults 10.7142857142857 mg/day 300 mg/dose intravenous injection, IV;IM,intramuscular injection; NebuPent pentamidine isethionate PDR
Max dose for geriatric 4.0 mg/kg/day 4 mg/kg/day intravenous injection, IV;IM,intramuscular injection; NebuPent pentamidine isethionate PDR
Max dose for geriatric 10.7142857142857 mg/dose 300 mg/dose intravenous injection, IV;IM,intramuscular injection; NebuPent pentamidine isethionate PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1