DETAILS

Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID	DDPD00736
Drug Name	Esomeprazole
Molecular Weight	345.416
Molecular Formula	C17H19N3O3S
CAS Number	119141-88-7
SMILES	COC1=CC2=C(NC(=N2)[S@@](=O)CC2=NC=C(C)C(OC)=C2C)C=C1
External Links
	DRUGBANK	DB00736
	T3DB	T3D2873
	PubChem Compound	9568614
	PDR	2278
	Drugs.com	Drugs.com Drug Page

Experimental Physicochemical Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Reference
Log P	0.6	-	0.6	-	DRUGBANK
Melting Point	155.0	℃	155	℃	DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Factor	Reference
AUC	3868.7	ng.h/ml	11.2	umol.h/L	Oral multiple dose;		DRUGBANK
AUC	1492.2	ng.h/ml	4.32	umol.h/L	Oral single dose;		DRUGBANK
Bioavailability	90.0	%	90	%	Oral multiple dose;		DRUGBANK
Bioavailability	64.0	%	64	%	Oral single dose;		DRUGBANK
Bioavailability	89.0	%	89（81-98）	%	PO, oral; Optical rotation S;		The Pharmacological Basis of Therapeutics
Bioavailability	53.0	%	53±29	%	PO, oral; Raceme D/L;		The Pharmacological Basis of Therapeutics
C Max	1554372.0	ng/ml	4.5(3.8-5.7)	mM	PO, oral; normal,healthy;		The Pharmacological Basis of Therapeutics
C Max	234882.9	ng/ml	0.68±0.43	mM	PO, oral; normal,healthy; extensive metabolizers, EM;		The Pharmacological Basis of Therapeutics
C Max	1208956.0	ng/ml	3.5±1.4	mM	PO, oral; normal,healthy; poor metabolizers, PM;		The Pharmacological Basis of Therapeutics
T Max	1.5	h	1.5	h	PO, oral;		DRUGBANK
T Max	1.5	h	1.5(1.3-1.7)	h	PO, oral; normal,healthy;		The Pharmacological Basis of Therapeutics
T Max	1.0	h	~1	h	PO, oral; normal,healthy; extensive metabolizers, EM;		The Pharmacological Basis of Therapeutics
T Max	3.5	h	~3-4	h	PO, oral; normal,healthy; poor metabolizers, PM;		The Pharmacological Basis of Therapeutics
Clearance	0.25	L/h/kg	4.1(3.3-5.0)	ml/min/kg		RD, renal impairment, Renal disease，including uremia ↓ ;	The Pharmacological Basis of Therapeutics
Clearance	0.45	L/h/kg	7.5±2.7	ml/min/kg		RD, renal impairment, Renal disease，including uremia ↓ ;	The Pharmacological Basis of Therapeutics
Clearance	0.23	L/h/kg	3.85	ml/min/kg	intravenous injection, IV; human, homo sapiens;		Human Intravenous Pharmacokinetic Dataset
Volume of Distribution	16.0	L	16.0	L	Apparent volume of distribution; normal,healthy;		DRUGBANK
Volume of Distribution	0.25	L/kg	0.25(0.23-0.27)	L/kg			The Pharmacological Basis of Therapeutics
Volume of Distribution	0.34	L/kg	0.34±0.09	L/kg			The Pharmacological Basis of Therapeutics
Volume of Distribution	0.20	L/kg	0.2	L/kg	intravenous injection, IV; human, homo sapiens;		Human Intravenous Pharmacokinetic Dataset
Half-life	1.3	h	1-1.5	h			DRUGBANK
Half-life	0.90	h	0.9(0.7-1.0)	h			The Pharmacological Basis of Therapeutics
Half-life	0.70	h	0.7±0.5	h		sever hepatic insufficiency ↑ ;	The Pharmacological Basis of Therapeutics
Half-life	0.83	h	0.83	h	intravenous injection, IV; human, homo sapiens;		Human Intravenous Pharmacokinetic Dataset
Eliminate Route	1.0	%	<1	%	Urinary excretion; Optical rotation S; Raceme D/L; Unchanged drug;		The Pharmacological Basis of Therapeutics
Protein Binding	97.0	%	97	%	plasma proteins;		DRUGBANK
Protein Binding	96.0	%	95-97	%	Optical rotation S; Raceme D/L;		The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Brand Name	Component	Reference
Max dose for neonates	0.5	mg/kg/day	0.5	mg/kg/day	PO, oral;intravenous injection, IV;	Nexium I.V.	esomeprazole sodium	PDR
Max dose for infants	1.33	mg/kg/day	1.33	mg/kg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR
Max dose for infants	0.5	mg/kg/day	0.5	mg/kg/day	intravenous injection, IV	Nexium I.V.	esomeprazole sodium	PDR
Max dose for infants	10.0	mg/day	10	mg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR
Max dose for infants	0.5	mg/kg/day	0.5	mg/kg/day	intravenous injection, IV	Nexium I.V.	esomeprazole sodium	PDR
Max dose for infants	5.0	mg/day	5	mg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR
Max dose for infants	0.5	mg/kg/day	0.5	mg/kg/day	intravenous injection, IV	Nexium I.V.	esomeprazole sodium	PDR
Max dose for infants	2.5	mg/day	2.5	mg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR
Max dose for infants	0.5	mg/kg/day	0.5	mg/kg/day	intravenous injection, IV	Nexium I.V.	esomeprazole sodium	PDR
Max dose for children	40.0	mg/day	40	mg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR
Max dose for children	80.0	mg/day	80	mg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR
Max dose for children	20.0	mg/day	20	mg/day	intravenous injection, IV	Nexium I.V.	esomeprazole sodium	PDR
Max dose for children	40.0	mg/day	40	mg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR
Max dose for children	80.0	mg/day	80	mg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR
Max dose for children	10.0	mg/day	10	mg/day	intravenous injection, IV	Nexium I.V.	esomeprazole sodium	PDR
Max dose for children	20.0	mg/day	20	mg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR
Max dose for children	20.0	mg/day	20	mg/day	intravenous injection, IV	Nexium I.V.	esomeprazole sodium	PDR
Max dose for children	3.3	mg/kg/day	3.3	mg/kg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR
Max dose for children	80.0	mg/day	80	mg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR
Max dose for children	20.0	mg/day	20	mg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR
Max dose for children	20.0	mg/day	20	mg/day	intravenous injection, IV	Nexium I.V.	esomeprazole sodium	PDR
Max dose for children	3.3	mg/kg/day	3.3	mg/kg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR
Max dose for children	80.0	mg/day	80	mg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR
Max dose for children	10.0	mg/day	10	mg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR
Max dose for children	10.0	mg/day	10	mg/day	intravenous injection, IV	Nexium I.V.	esomeprazole sodium	PDR
Max dose for children	3.3	mg/kg/day	3.3	mg/kg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR
Max dose for children	40.0	mg/day	40	mg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR
Max dose for adolescents	40.0	mg/day	40	mg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR
Max dose for adolescents	80.0	mg/day	80	mg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR
Max dose for adolescents	20.0	mg/day	20	mg/day	intravenous injection, IV	Nexium I.V.	esomeprazole sodium	PDR
Max dose for adolescents	40.0	mg/day	40	mg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR
Max dose for adolescents	80.0	mg/day	80	mg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR
Max dose for adolescents	10.0	mg/day	10	mg/day	intravenous injection, IV	Nexium I.V.	esomeprazole sodium	PDR
Max dose for adults	20.0	mg/day	20	mg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR
Max dose for adults	40.0	mg/day	40	mg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR
Max dose for adults	80.0	mg/day	80	mg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR
Max dose for adults	40.0	mg/day	40	mg/day	intravenous injection, IV	Nexium I.V.	esomeprazole sodium	PDR
Max dose for adults	80.0	mg/dose	80	mg/dose	intravenous injection, IV	Nexium I.V.	esomeprazole sodium	PDR
Max dose for adults	240.0	mg/day	240	mg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR
Max dose for geriatric	20.0	mg/day	20	mg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR
Max dose for geriatric	40.0	mg/day	40	mg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR
Max dose for geriatric	80.0	mg/day	80	mg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR
Max dose for geriatric	40.0	mg/day	40	mg/day	intravenous injection, IV	Nexium I.V.	esomeprazole sodium	PDR
Max dose for geriatric	80.0	mg/dose	80	mg/dose	intravenous injection, IV	Nexium I.V.	esomeprazole sodium	PDR
Max dose for geriatric	240.0	mg/day	240	mg/day	PO, oral	Nexium I.V.	esomeprazole sodium	PDR

Drug Property Radar Chart

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1