Basic Information
| Drug ID | DDPD00731 |
|
| Drug Name | Nateglinide | |
| Molecular Weight | 317.429 | |
| Molecular Formula | C19H27NO3 | |
| CAS Number | 105816-04-4 | |
| SMILES | CC(C)[C@H]1CC[C@@H](CC1)C(=O)N[C@H](CC1=CC=CC=C1)C(O)=O | |
| External Links | ||
| DRUGBANK | DB00731 | |
| PubChem Compound | 5311309 | |
| PDR | 1210 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 2.4 | - | 2.4 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 73.0 | % | 73 | % | PO, oral; | DRUGBANK |
| T Max | 1.0 | h | 1 | h | PO, oral; | DRUGBANK |
| Clearance | 0.11 | L/h/kg | 1.8 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 10.0 | L | 10.0 | L | normal,healthy; | DRUGBANK | Volume of Distribution | 0.15 | L/kg | 0.15 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 1.5 | h | 1.5 | h | DRUGBANK | Half-life | 1.5 | h | 1.5 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 83.0 | % | 83 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 10.0 | % | 10 | % | Faeces excretion; | DRUGBANK |
| Protein Binding | 98.0 | % | 98 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 360.0 | mg/day | 360 | mg/day | PO, oral | Starlix | nateglinide | PDR |
| Max dose for elderly | 360.0 | mg/day | 360 | mg/day | PO, oral | Starlix | nateglinide | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1