Basic Information
| Drug ID | DDPD00728 |
|
| Drug Name | Rocuronium | |
| Molecular Weight | 529.7742 | |
| Molecular Formula | C32H53N2O4 | |
| CAS Number | 143558-00-3 | |
| SMILES | [H][C@@]12C[C@@H]([C@H](OC(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])C[C@H](O)[C@H](C[C@]12C)N1CCOCC1)[N+]1(CC=C)CCCC1 | |
| External Links | ||
| DRUGBANK | DB00728 | |
| PubChem Compound | 441290 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| C Max | 1100.0 | ng/ml | 0.8-1.4 | mcg/ml | intravenous injection, IV; | The Pharmacological Basis of Therapeutics | |
| Clearance | 0.25 | L/h/kg | 0.25 | L/kg/h | adults; | DRUGBANK | Clearance | 0.21 | L/h/kg | 0.21 | L/kg/h | Elderly; | DRUGBANK | Clearance | 0.16 | L/h/kg | 0.16 | L/kg/h | normal,healthy; | DRUGBANK | Clearance | 0.13 | L/h/kg | 0.13 | L/kg/h | organ transplants; | DRUGBANK | Clearance | 0.13 | L/h/kg | 0.13 | L/kg/h | hepatopathy，LD; | DRUGBANK | Clearance | 0.35 | L/h/kg | 0.35±0.08 | L/kg/h | pediatric patients; Infants; | DRUGBANK | Clearance | 0.38 | L/h/kg | 0.32-0.44 | L/kg/h | pediatric patients; Children; | DRUGBANK | Clearance | 0.26 | L/h/kg | 3.3-5.2 | ml/min/kg | Average clearance; Bile excretion; | Children ↑ ;hepatopathy，LD → ; | The Pharmacological Basis of Therapeutics | Clearance | 0.22 | L/h/kg | 3.7 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.30 | L/kg | 0.3 | L/kg | Infants; | DRUGBANK | Volume of Distribution | 0.24 | L/kg | 0.21-0.26 | L/kg | Children; | DRUGBANK | Volume of Distribution | 0.25 | L/kg | 0.19-0.31 | L/kg | Average volume of distribution; Bile excretion; | hepatopathy，LD ↑ ; | The Pharmacological Basis of Therapeutics | Volume of Distribution | 0.21 | L/kg | 0.21 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 0.0250 | h | 1-2 | min | rapid distribution half-life; | RD, renal impairment, Renal disease，including uremia → ; | DRUGBANK | Half-life | 0.27 | h | 14-18 | min | rapid distribution half-life; | DRUGBANK | Half-life | 0.29 | h | ~15-20 | min | hepatopathy，LD; | DRUGBANK | Half-life | 1.7 | h | 1.2-2.2 | h | different study; | Children ↓ ;chronic liver disease ↑ ; | The Pharmacological Basis of Therapeutics | Half-life | 1.6 | h | 1.6 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 17.0 | % | 12-22 | % | Urinary excretion; Unchanged drug; | The Pharmacological Basis of Therapeutics | |
| Protein Binding | 30.0 | % | ~30 | % | plasma proteins; human, homo sapiens; | DRUGBANK | Protein Binding | 25.0 | % | 25 | % | The Pharmacological Basis of Therapeutics |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1