Basic Information
| Drug ID | DDPD00726 |
|
| Drug Name | Trimipramine | |
| Molecular Weight | 294.4338 | |
| Molecular Formula | C20H26N2 | |
| CAS Number | 739-71-9 | |
| SMILES | CC(CN(C)C)CN1C2=CC=CC=C2CCC2=CC=CC=C12 | |
| External Links | ||
| DRUGBANK | DB00726 | |
| T3DB | T3D2870 | |
| PubChem Compound | 5584 | |
| PDR | 1603 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 4.2 | - | 4.2 | - | DRUGBANK |
| Melting Point | 45.0 | ℃ | 45 | ℃ | PhysProp |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 0.96 | L/h/kg | 16 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 16.0 | L/kg | 16 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 14.5 | h | 11-18 | h | DRUGBANK | Half-life | 23.0 | h | 23 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Protein Binding | 94.5 | % | 93-96 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adolescents | 100.0 | mg/day | 100 | mg/day | PO, oral | Surmontil | trimipramine maleate | PDR |
| Max dose for adults | 200.0 | mg/day | 200 | mg/day | PO, oral | Surmontil | trimipramine maleate | PDR |
| Max dose for adults | 300.0 | mg/day | 300 | mg/day | PO, oral | Surmontil | trimipramine maleate | PDR |
| Max dose for elderly | 100.0 | mg/day | 100 | mg/day | PO, oral | Surmontil | trimipramine maleate | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1