Basic Information
| Drug ID | DDPD00718 |
|
| Drug Name | Adefovir dipivoxil | |
| Molecular Weight | 501.4705 | |
| Molecular Formula | C20H32N5O8P | |
| CAS Number | 142340-99-6 | |
| SMILES | CC(C)(C)C(=O)OCOP(=O)(COCCN1C=NC2=C(N)N=CN=C12)OCOC(=O)C(C)(C)C | |
| External Links | ||
| DRUGBANK | DB00718 | |
| PubChem Compound | 60871 | |
| PDR | 2252 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 1.91 | - | 1.91 | - | FDA label |
| Water Solubility | 19000.0 | mg/L | 19 mg/mL at pH 2.0 | mg/ml | FDA label | Water Solubility | 400.0 | mg/L | 0.4 mg/mL at pH 7.2 | mg/ml | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| AUC | 220.0 | ng.h/ml | 220±70 | ng.h/ml | Oral single dose; Hepatitis, Hep; food; | food → ; | DRUGBANK |
| Bioavailability | 59.0 | % | 59 | % | PO, oral; | DRUGBANK | |
| C Max | 18.4 | ng/ml | 18.4±6.26 | ng/ml | Oral single dose; Hepatitis, Hep; food; | food → ; | DRUGBANK |
| T Max | 2.3 | h | 0.58-4 | h | Oral single dose; Hepatitis, Hep; food; | food → ; | DRUGBANK |
| Metabolic | 45.0 | % | 45 | % | Urinary excretion; | DRUGBANK | |
| Clearance | 28.1 | L/h | 469±99.0 | ml/min | normal,healthy; patients; | DRUGBANK | Clearance | 21.4 | L/h | 356±85.6 | ml/min | mild renal function; patients; | DRUGBANK | Clearance | 14.2 | L/h | 237±118 | ml/min | moderate renal function; patients; | DRUGBANK | Clearance | 5.5 | L/h | 91.7±51.3 | ml/min | severe renal function; patients; | DRUGBANK |
| Volume of Distribution | 0.39 | L/kg | 392±75 | mL/kg | at steady state; intravenous injection, IV; | DRUGBANK | Volume of Distribution | 0.35 | L/kg | 352±9 | mL/kg | at steady state; intravenous injection, IV; | DRUGBANK |
| Half-life | 7.5 | h | 7.48±1.65 | h | elimination half-life; | DRUGBANK | |
| Protein Binding | 4.0 | % | 4 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 10.0 | mg/day | 10 | mg/day | PO, oral | Hepsera | adefovir dipivoxil | PDR |
| Max dose for children | 0.25 | mg/kg/day | 0.25 | mg/kg/day | PO, oral | Hepsera | adefovir dipivoxil | PDR |
| Max dose for children | 10.0 | mg/day | 10 | mg/day | PO, oral | Hepsera | adefovir dipivoxil | PDR |
| Max dose for children | 0.3 | mg/kg/day | 0.3 | mg/kg/day | PO, oral | Hepsera | adefovir dipivoxil | PDR |
| Max dose for adolescents | 10.0 | mg/kg | 10 | mg/kg | PO, oral | Hepsera | adefovir dipivoxil | PDR |
| Max dose for adults | 10.0 | mg/kg | 10 | mg/kg | PO, oral | Hepsera | adefovir dipivoxil | PDR |
| Max dose for geriatric | 10.0 | mg/kg | 10 | mg/kg | PO, oral | Hepsera | adefovir dipivoxil | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1