Basic Information
| Drug ID | DDPD00717 |
|
| Drug Name | Norethisterone | |
| Molecular Weight | 298.4192 | |
| Molecular Formula | C20H26O2 | |
| CAS Number | 68-22-4 | |
| SMILES | [H][C@@]12CC[C@@](O)(C#C)[C@@]1(C)CC[C@]1([H])[C@@]3([H])CCC(=O)C=C3CC[C@@]21[H] | |
| External Links | ||
| DRUGBANK | DB00717 | |
| T3DB | T3D4745 | |
| PubChem Compound | 6230 | |
| PDR | 1526 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Melting Point | 202.0 | ℃ | 202-208 | ℃ | Canadian Jencycla label |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 33.5 | ng.h/ml | 30-37 | ng.h/ml | Oral single dose; | DRUGBANK |
| Bioavailability | 64.0 | % | 64 | % | PO, oral; | DRUGBANK |
| C Max | 6.4 | ng/ml | 5.39-7.36 | ng/ml | Oral single dose; | DRUGBANK | C Max | 0.84 | ng/ml | 617-1060 | pg/ml | skin/dermal; | DRUGBANK |
| T Max | 1.5 | h | 1-2 | h | Oral single dose; | DRUGBANK |
| Tss | 24.0 | h | 24 | h | skin/dermal; | DRUGBANK |
| Clearance | 0.40 | L/h/kg | 0.4 | L/h/kg | Plasma clearance; | DRUGBANK | Clearance | 77.0 | L/h | ~73-81 | L/h | Total clearance; | DRUGBANK |
| Volume of Distribution | 4.0 | L/kg | ~4 | L/kg | DRUGBANK | |
| Half-life | 9.0 | h | 8-10 | h | DRUGBANK | |
| Toxicity LD50 | 6000.0 | mg/kg | 6.0 | g/kg | PO, oral; mouse; | DRUGBANK |
| Toxicity TDLo | 42.0 | mg/kg | 42.0 | mg/kg | human, homo sapiens; Female, women; | DRUGBANK |
| Eliminate Route | 50.0 | % | >50 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 30.0 | % | 20-40 | % | Faeces excretion; | DRUGBANK |
| Protein Binding | 61.0 | % | 61 | % | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1