Basic Information
| Drug ID | DDPD00716 |
|
| Drug Name | Nedocromil | |
| Molecular Weight | 371.3408 | |
| Molecular Formula | C19H17NO7 | |
| CAS Number | 69049-73-6 | |
| SMILES | CCCC1=C2N(CC)C(=CC(=O)C2=CC2=C1OC(=CC2=O)C(O)=O)C(O)=O | |
| External Links | ||
| DRUGBANK | DB00716 | |
| PubChem Compound | 50294 | |
| PDR | 1114 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 2.22 | - | 2.22 | - | SANGSTER (1994) |
| Melting Point | 299.0 | ℃ | 299 | ℃ | PhysProp |
| Water Solubility | 145.0 | mg/L | 145 | mg/L | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Metabolic | 0 | % | 0 | % | intravenous injection, IV; | DRUGBANK |
| Clearance | 0.61 | L/h/kg | 10.2 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.43 | L/kg | 0.43 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 3.3 | h | ~3.3 | h | DRUGBANK | Half-life | 0.90 | h | 0.9 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 70.0 | % | 70 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 30.0 | % | 3 | % | Faeces excretion; | DRUGBANK | Eliminate Route | 70.0 | % | 70 | % | Urinary excretion; Unchanged drug; | DRUGBANK | Eliminate Route | 30.0 | % | 30 | % | Faeces excretion; Unchanged drug; | DRUGBANK |
| Protein Binding | 89.0 | % | ~89 | % | plasma proteins; human, homo sapiens; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 8.0 | sprays/day | 8 | sprays/day | inhalation, IH | Alocril | nedocromil sodium | PDR |
| Max dose for children | 14.0 | mg/day | 14 | mg/day | inhalation, IH | Alocril | nedocromil sodium | PDR |
| Max dose for adolescents | 8.0 | sprays/day | 8 | sprays/day | inhalation, IH | Alocril | nedocromil sodium | PDR |
| Max dose for adolescents | 14.0 | mg/day | 14 | mg/day | inhalation, IH | Alocril | nedocromil sodium | PDR |
| Max dose for adults | 8.0 | sprays/day | 8 | sprays/day | inhalation, IH | Alocril | nedocromil sodium | PDR |
| Max dose for adults | 14.0 | mg/day | 14 | mg/day | inhalation, IH | Alocril | nedocromil sodium | PDR |
| Max dose for elderly | 8.0 | sprays/day | 8 | sprays/day | inhalation, IH | Alocril | nedocromil sodium | PDR |
| Max dose for elderly | 14.0 | mg/day | 14 | mg/day | inhalation, IH | Alocril | nedocromil sodium | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1