Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00715 ...
Drug Name Paroxetine
Molecular Weight 329.3654
Molecular Formula C19H20FNO3
CAS Number 61869-08-7
SMILES FC1=CC=C(C=C1)[C@@H]1CCNC[C@H]1COC1=CC2=C(OCO2)C=C1
External Links
DRUGBANK DB00715
T3DB T3D2868
PubChem Compound 43815
PDR 1593
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.53 - 2.53 - https://ca.gsk.com/media/530543/paxil_pm-2014-11-13.pdf
Boiling Point 451.7 ℃ 451.7±45.0 ℃ http://www.chemspider.com/Chemical-Structure.39888.html
Melting Point 129.0 ℃ 120-138 ℃ https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/020031s060,020936s037,020710s024lbl.pdf
Water Solubility 5400.0 mg/L 5.4 mg/ml https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/020031s060,020936s037,020710s024lbl.pdf
pKa 9.9 - 9.9 - https://ca.gsk.com/media/530543/paxil_pm-2014-11-13.pdf

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
AUC 574.0 ng.h/ml 574.0 ng.h/ml PO, oral; DRUGBANK
AUC 1053.0 ng.h/ml 1053.0 ng.h/ml PO, oral; moderate renal function; DRUGBANK
Bioavailability 45.0 % 30-60 % PO, oral; DRUGBANK
C Max 42.8 ng/ml ~130 nM PO, oral; extensive metabolizers, EM; The Pharmacological Basis of Therapeutics
C Max 72.5 ng/ml ~220 nM PO, oral; poor metabolizers, PM; The Pharmacological Basis of Therapeutics
T Max 4.3 h 4.3(2-8) h PO, oral; DRUGBANK
T Max 5.2 h 5.2±0.5 h PO, oral; adults; The Pharmacological Basis of Therapeutics
Tss 252.0 h 7-14 day PO, oral; DRUGBANK
Clearance 167.0 L/h 167.0 L/h Total clearance; PO, oral; Liver metabolism; RD, renal impairment, Renal disease，including uremia ↓ ; DRUGBANK
Clearance 0.52 L/h/kg 8.6±3.2 ml/min/kg apparent clearance; hydrolysis; Elderly ↓ ;Hepatic cirrhosis, cirr ↓ ; The Pharmacological Basis of Therapeutics
Clearance 1.1 L/h/kg 18 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 17.0 L/kg 17±10 L/kg Apparent volume of distribution; The Pharmacological Basis of Therapeutics
Volume of Distribution 18.0 L/kg 18 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 21.0 h ~21 h elimination half-life; DRUGBANK
Half-life 17.3 h 17.3 h elimination half-life; normal,healthy; young; DRUGBANK
Half-life 60.0 h 1-4 day different study; DRUGBANK
Half-life 17.0 h 17±3 h Multiple dose; extensive metabolizers, EM; Hepatic cirrhosis, cirr ↑ ;Age ↑ ; The Pharmacological Basis of Therapeutics
Half-life 41.0 h 41±8 h Multiple dose; poor metabolizers, PM; Hepatic cirrhosis, cirr ↑ ;Age ↑ ; The Pharmacological Basis of Therapeutics
Half-life 13.0 h 13 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 350.0 mg/kg 350.0 mg/kg mouse; Rattus, Rat; DRUGBANK
Toxicity LD50 500.0 mg/kg 500.0 mg/kg PO, oral; mouse; T3DB
Eliminate Route 64.0 % ~64 % Urinary excretion; PO, oral; DRUGBANK
Eliminate Route 36.0 % ~36 % Faeces excretion; PO, oral; DRUGBANK
Eliminate Route 3.0 % 3 % Unchanged drug; DRUGBANK
Eliminate Route 2.0 % <2 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 95.0 % 95 % plasma proteins; DRUGBANK
Protein Binding 95.0 % 95 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 50.0 mg/day 50 mg/day PO, oral Pexeva paroxetine mesylate PDR
Max dose for adolescents 50.0 mg/day 50 mg/day PO, oral Pexeva paroxetine mesylate PDR
Max dose for adults 60.0 mg/day 60 mg/day PO, oral Pexeva paroxetine mesylate PDR
Max dose for adults 75.0 mg/day 75 mg/day PO, oral Pexeva paroxetine mesylate PDR
Max dose for geriatric 40.0 mg/day 40 mg/day PO, oral Pexeva paroxetine mesylate PDR
Max dose for geriatric 50.0 mg/day 50 mg/day PO, oral Pexeva paroxetine mesylate PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1