Basic Information
| Drug ID | DDPD00714 |
|
| Drug Name | Apomorphine | |
| Molecular Weight | 267.3224 | |
| Molecular Formula | C17H17NO2 | |
| CAS Number | 58-00-4 | |
| SMILES | [H][C@]12CC3=C(C(O)=C(O)C=C3)C3=CC=CC(CCN1C)=C23 | |
| External Links | ||
| DRUGBANK | DB00714 | |
| T3DB | T3D2867 | |
| PubChem Compound | 6005 | |
| PDR | 2459 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 2.0 | - | 2.0 | - | Borkar et al, 2017 |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| T Max | 0.25 | h | 10-20 | min | DRUGBANK | |
| Clearance | 1440.0 | L/h | 1440.0 | L/h | sublingual; | DRUGBANK | Clearance | 223.0 | L/h | 223.0 | L/h | intravenous injection, IV; | DRUGBANK | Clearance | 2.4 | L/h/kg | 40 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 263.5 | L | 123-404 | L | Apparent volume of distribution; subcutaneous injection, SC; | DRUGBANK | Volume of Distribution | 3630.0 | L | 3630.0 | L | Apparent volume of distribution; sublingual; | DRUGBANK | Volume of Distribution | 1.6 | L/kg | 1.6 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 1.7 | h | 1.7 | h | elimination half-life; Intraperitoneal, IP; | DRUGBANK | Half-life | 0.83 | h | 50 | min | elimination half-life; intravenous injection, IV; | DRUGBANK | Half-life | 0.68 | h | 0.68 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 0.15 | mg/kg | 145.0 | ug/kg | Intraperitoneal, IP; mouse; | DRUGBANK | Toxicity LD50 | 160.4 | mg/kg | 0.6 | mmole/kg | Intraperitoneal, IP; mouse; | T3DB |
| Protein Binding | 99.9 | % | 99.9 | % | human, homo sapiens; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 0.6 | ml/dose | 0.6 | ml/dose | subcutaneous injection, SC | Apokyn | apomorphine hydrochloride | PDR |
| Max dose for adults | 6.0 | mg/dose | 6 | mg/dose | subcutaneous injection, SC | Apokyn | apomorphine hydrochloride | PDR |
| Max dose for adults | 2.0 | ml/day | 2 | ml/day | subcutaneous injection, SC | Apokyn | apomorphine hydrochloride | PDR |
| Max dose for adults | 20.0 | mg/day | 20 | mg/day | subcutaneous injection, SC | Apokyn | apomorphine hydrochloride | PDR |
| Max dose for adults | 30.0 | mg/dose | 30 | mg/dose | sublingual | Apokyn | apomorphine hydrochloride | PDR |
| Max dose for adults | 5.0 | dose/day | 5 | dose/day | sublingual | Apokyn | apomorphine hydrochloride | PDR |
| Max dose for geriatric | 0.6 | ml/dose | 0.6 | ml/dose | subcutaneous injection, SC | Apokyn | apomorphine hydrochloride | PDR |
| Max dose for geriatric | 6.0 | mg/dose | 6 | mg/dose | subcutaneous injection, SC | Apokyn | apomorphine hydrochloride | PDR |
| Max dose for geriatric | 2.0 | ml/day | 2 | ml/day | subcutaneous injection, SC | Apokyn | apomorphine hydrochloride | PDR |
| Max dose for geriatric | 20.0 | mg/day | 20 | mg/day | subcutaneous injection, SC | Apokyn | apomorphine hydrochloride | PDR |
| Max dose for geriatric | 30.0 | mg/dose | 30 | mg/dose | sublingual | Apokyn | apomorphine hydrochloride | PDR |
| Max dose for geriatric | 5.0 | dose/day | 5 | dose/day | sublingual | Apokyn | apomorphine hydrochloride | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1